102158 20230519145439.0 doi 10.1039/d0na00873g sideral 124099 ART-2021-124099 eng Idiago López, J. (orcid)0000-0002-3373-9341 Nanoparticles and bioorthogonal chemistry joining forces for improved biomedical applications 2021 Access copy available to the general public Unrestricted Bioorthogonal chemistry comprises chemical reactions that can take place inside complex biological environments, providing outstanding tools for the investigation and elucidation of biological processes. Its use in combination with nanotechnology can lead to further developments in diverse areas of biomedicine, such as molecular bioimaging, targeted delivery, in situdrug activation, study of cell-nanomaterial interactions, biosensing, etc.Here, we summarise the recent efforts to bring together the unique properties of nanoparticles and the remarkable features of bioorthogonal reactions to create a toolbox of new or improved biomedical applications. We show how, by joining forces, bioorthogonal chemistry and nanotechnology can overcome some of the key current limitations in the field of nanomedicine, providing better, faster and more sensitive nanoparticle-based bioimaging and biosensing techniques, as well as therapeutic nanoplatforms with superior efficacy. info:eu-repo/grantAgreement/EC/H2020/657215/EU/Cell-surface immobilized vs. internalized magnetic nanoparticles for magnetic hyperthermia studies/OUTstandINg This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 657215-OUTstandINg info:eu-repo/grantAgreement/ES/MECD/FPU17-02024 info:eu-repo/grantAgreement/EUR/M-ERA.NET/COFUND-MagicCellGene-PCIN-2017-060 info:eu-repo/grantAgreement/ES/MINECO/BIO2017-84246-C2-1-R info:eu-repo/grantAgreement/ES/MINECO/PGC2018-096016-B-I00 info:eu-repo/grantAgreement/ES/MINECO/RYC-2015-17640 info:eu-repo/semantics/openAccess by-nc http://creativecommons.org/licenses/by-nc/3.0/es/ 5.598 2021 CHEMISTRY, MULTIDISCIPLINARY 56 / 180 = 0.311 2021 Q2 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 111 / 345 = 0.322 2021 Q2 T1 NANOSCIENCE & NANOTECHNOLOGY 55 / 109 = 0.505 2021 Q3 T2 1.043 2021 Atomic and Molecular Physics, and Optics 2021 Q1 Materials Science (miscellaneous) 2021 Q1 Engineering (miscellaneous) 2021 Q1 Bioengineering 2021 Q1 5.7 2021 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Moreno Antolín, E. (orcid)0000-0002-8223-3267 Fuente, J.M. de la (orcid)0000-0003-1081-8482 Fratila, R.M. (orcid)0000-0001-5559-8757 3, 5 (2021), 1261-1292 Nanoscale Advances 2516-0230 3185110 http://zaguan.unizar.es/record/102158/files/texto_completo.pdf Versión publicada 3015562 http://zaguan.unizar.es/record/102158/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:102158 articulos driver 2023-05-18-14:29:06 ARTICLE