000102173 001__ 102173
000102173 005__ 20230519145441.0
000102173 0247_ $$2doi$$a10.3390/ijms22052372
000102173 0248_ $$2sideral$$a124125
000102173 037__ $$aART-2021-124125
000102173 041__ $$aeng
000102173 100__ $$0(orcid)0000-0002-8890-4869$$aFerrer-Pérez, Carmen$$uUniversidad de Zaragoza
000102173 245__ $$aOxytocin signaling as a target to block social defeat-induced increases in drug abuse reward
000102173 260__ $$c2021
000102173 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102173 5203_ $$aThere is huge scientific interest in the neuropeptide oxytocin (OXT) due to its putative capacity to modulate a wide spectrum of physiological and cognitive processes including motivation, learning, emotion, and the stress response. The present review seeks to increase the understanding of the role of OXT in an individual’s vulnerability or resilience with regard to developing a substance use disorder. It places specific attention on the role of social stress as a risk factor of addiction, and explores the hypothesis that OXT constitutes a homeostatic response to stress that buffers against its negative impact. For this purpose, the review summarizes preclinical and clinical literature regarding the effects of OXT in different stages of the addiction cycle. The current literature affirms that a well-functioning oxytocinergic system has protective effects such as the modulation of the initial response to drugs of abuse, the attenuation of the development of dependence, the blunting of drug reinstatement and a general anti-stress effect. However, this system is dysregulated if there is continuous drug use or chronic exposure to stress. In this context, OXT is emerging as a promising pharmacotherapy to restore its natural beneficial effects in the organism and to help rebalance the functions of the addicted brain.
000102173 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R
000102173 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000102173 590__ $$a6.208$$b2021
000102173 592__ $$a1.176$$b2021
000102173 594__ $$a6.9$$b2021
000102173 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b69 / 297 = 0.232$$c2021$$dQ1$$eT1
000102173 593__ $$aComputer Science Applications$$c2021$$dQ1
000102173 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b50 / 180 = 0.278$$c2021$$dQ2$$eT1
000102173 593__ $$aInorganic Chemistry$$c2021$$dQ1
000102173 593__ $$aSpectroscopy$$c2021$$dQ1
000102173 593__ $$aOrganic Chemistry$$c2021$$dQ1
000102173 593__ $$aPhysical and Theoretical Chemistry$$c2021$$dQ1
000102173 593__ $$aMolecular Biology$$c2021$$dQ1
000102173 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000102173 700__ $$aReguilón, Marina D.
000102173 700__ $$aMiñarro, José
000102173 700__ $$aRodríguez-Arias, Marta
000102173 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000102173 773__ $$g22, 5 (2021), 2372 [21 pp]$$pInt. j. mol. sci.$$tInternational Journal of Molecular Sciences$$x1661-6596
000102173 8564_ $$s1285456$$uhttps://zaguan.unizar.es/record/102173/files/texto_completo.pdf$$yVersión publicada
000102173 8564_ $$s2713938$$uhttps://zaguan.unizar.es/record/102173/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000102173 909CO $$ooai:zaguan.unizar.es:102173$$particulos$$pdriver
000102173 951__ $$a2023-05-18-14:33:16
000102173 980__ $$aARTICLE