102173 20230519145441.0 doi 10.3390/ijms22052372 sideral 124125 ART-2021-124125 eng Ferrer-Pérez, Carmen Universidad de Zaragoza (orcid)0000-0002-8890-4869 Oxytocin signaling as a target to block social defeat-induced increases in drug abuse reward 2021 Access copy available to the general public Unrestricted There is huge scientific interest in the neuropeptide oxytocin (OXT) due to its putative capacity to modulate a wide spectrum of physiological and cognitive processes including motivation, learning, emotion, and the stress response. The present review seeks to increase the understanding of the role of OXT in an individual’s vulnerability or resilience with regard to developing a substance use disorder. It places specific attention on the role of social stress as a risk factor of addiction, and explores the hypothesis that OXT constitutes a homeostatic response to stress that buffers against its negative impact. For this purpose, the review summarizes preclinical and clinical literature regarding the effects of OXT in different stages of the addiction cycle. The current literature affirms that a well-functioning oxytocinergic system has protective effects such as the modulation of the initial response to drugs of abuse, the attenuation of the development of dependence, the blunting of drug reinstatement and a general anti-stress effect. However, this system is dysregulated if there is continuous drug use or chronic exposure to stress. In this context, OXT is emerging as a promising pharmacotherapy to restore its natural beneficial effects in the organism and to help rebalance the functions of the addicted brain. info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007 info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.208 2021 BIOCHEMISTRY & MOLECULAR BIOLOGY 69 / 297 = 0.232 2021 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 50 / 180 = 0.278 2021 Q2 T1 1.176 2021 Computer Science Applications 2021 Q1 Inorganic Chemistry 2021 Q1 Spectroscopy 2021 Q1 Organic Chemistry 2021 Q1 Physical and Theoretical Chemistry 2021 Q1 Molecular Biology 2021 Q1 6.9 2021 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Reguilón, Marina D. Miñarro, José Rodríguez-Arias, Marta 4009 735 Universidad de Zaragoza Dpto. Psicología y Sociología Área Psicolog.Evolut.Educac 22, 5 (2021), 2372 [21 pp] Int. j. mol. sci. International Journal of Molecular Sciences 1661-6596 1285456 http://zaguan.unizar.es/record/102173/files/texto_completo.pdf Versión publicada 2713938 http://zaguan.unizar.es/record/102173/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:102173 articulos driver 2023-05-18-14:33:16 ARTICLE