102178 20230519145442.0 doi 10.3390/ani11030691 sideral 124133 ART-2021-124133 eng Acín, Cristina Universidad de Zaragoza (orcid)0000-0001-5105-6133 Classical and atypical scrapie in sheep and goats: Review on the etiology, genetic factors, pathogenesis, diagnosis, and control measures of both diseases 2021 Access copy available to the general public Unrestricted Prion diseases, such as scrapie, are neurodegenerative diseases with a fatal outcome, caused by a conformational change of the cellular prion protein (PrPC), originating with the pathogenic form (PrPSc). Classical scrapie in small ruminants is the paradigm of prion diseases, as it was the first transmissible spongiform encephalopathy (TSE) described and is the most studied. It is necessary to understand the etiological properties, the relevance of the transmission pathways, the infectivity of the tissues, and how we can improve the detection of the prion protein to encourage detection of the disease. The aim of this review is to perform an overview of classical and atypical scrapie disease in sheep and goats, detailing those special issues of the disease, such as genetic fac-tors, diagnostic procedures, and surveillance approaches carried out in the European Union with the objective of controlling the dissemination of scrapie disease. info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 3.231 2021 VETERINARY SCIENCES 16 / 145 = 0.11 2021 Q1 T1 AGRICULTURE, DAIRY & ANIMAL SCIENCE 13 / 63 = 0.206 2021 Q1 T1 0.61 2021 Veterinary (miscellaneous) 2021 Q1 Animal Science and Zoology 2021 Q1 2.7 2021 info:eu-repo/semantics/review info:eu-repo/semantics/publishedVersion Bolea, Rosa Universidad de Zaragoza (orcid)0000-0002-2746-3932 Monzón, Marta Universidad de Zaragoza (orcid)0000-0002-2787-9671 Monleón, Eva Universidad de Zaragoza (orcid)0000-0002-7453-1766 Moreno, Bernardino Universidad de Zaragoza (orcid)0000-0001-6629-6842 Filali, Hicham (orcid)0000-0003-3352-740X Marín, Belén Universidad de Zaragoza (orcid)0000-0002-1590-3347 Sola, Diego Universidad de Zaragoza Betancor, Marina Universidad de Zaragoza (orcid)0000-0002-0388-9429 Guijarro, Isabel M. (orcid)0000-0001-9773-7460 García, Mirta Universidad de Zaragoza (orcid)0000-0002-8752-5146 Vargas, Antonio (orcid)0000-0002-6158-691X Badiola, Juan José Universidad de Zaragoza (orcid)0000-0002-7173-7216 1009 773 Universidad de Zaragoza Dpto. Patología Animal Área Sanidad Animal 1003 443 Universidad de Zaragoza Dpto. Anatom.Histolog.Humanas Area Histología 11, 3 (2021), 691 [20 pp.] Animals (Basel) Animals 2076-2615 1188484 http://zaguan.unizar.es/record/102178/files/texto_completo.pdf Versión publicada 2775528 http://zaguan.unizar.es/record/102178/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:102178 articulos driver 2023-05-18-14:34:10 ARTICLE