000102180 001__ 102180
000102180 005__ 20241024130536.0
000102180 0247_ $$2doi$$a10.1126/sciadv.abf9180
000102180 0248_ $$2sideral$$a124138
000102180 037__ $$aART-2021-124138
000102180 041__ $$aeng
000102180 100__ $$aDuro-Castano, A.
000102180 245__ $$aTargeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates
000102180 260__ $$c2021
000102180 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102180 5203_ $$aAlzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as evidenced by an increase in dendritic density of pyramidal neurons in organotypic hippocampal culture. The additional conjugation of the Angiopep-2 targeting moiety enhanced nanoconjugate passage through the blood-brain barrier and modulated brain distribution with nanoconjugate accumulation in neurogenic areas, including the olfactory bulb. Nanoconjugate treatment effectively reduced neurotoxic amyloid aggregate levels and rescued impairments to olfactory memory and object recognition in APP/PS1 transgenic AD model mice. Overall, this study provides a description of a targeted multimodal polyglutamate-based nanoconjugate with neuroprotective and neurotrophic potential for AD treatment. Copyright
000102180 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000102180 590__ $$a14.98$$b2021
000102180 591__ $$aMULTIDISCIPLINARY SCIENCES$$b7 / 74 = 0.095$$c2021$$dQ1$$eT1
000102180 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000102180 700__ $$aBorrás, C.
000102180 700__ $$aHerranz-Pérez, V.
000102180 700__ $$0(orcid)0000-0001-5990-1266$$aBlanco-Gandía, M.C.$$uUniversidad de Zaragoza
000102180 700__ $$aConejos-Sánchez, I.
000102180 700__ $$aArmiñán, A.
000102180 700__ $$aMas-Bargues, C.
000102180 700__ $$aInglés, M.
000102180 700__ $$aMiñarro, J.
000102180 700__ $$aRodríguez-Arias, M.
000102180 700__ $$aGarcía-Verdugo, J.M.
000102180 700__ $$aViña, J.
000102180 700__ $$aVicent, M.J.
000102180 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000102180 773__ $$g7, 13 (2021), [16 pp]$$pSci. adv.$$tScience advances$$x2375-2548
000102180 8564_ $$s4440900$$uhttps://zaguan.unizar.es/record/102180/files/texto_completo.pdf$$yVersión publicada
000102180 8564_ $$s3736427$$uhttps://zaguan.unizar.es/record/102180/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000102180 909CO $$ooai:zaguan.unizar.es:102180$$particulos$$pdriver
000102180 951__ $$a2024-10-24-13:01:43
000102180 980__ $$aARTICLE