000102199 001__ 102199
000102199 005__ 20230519145458.0
000102199 0247_ $$2doi$$a10.1080/02656736.2021.1892837
000102199 0248_ $$2sideral$$a124242
000102199 037__ $$aART-2021-124242
000102199 041__ $$aeng
000102199 100__ $$aWells, J.
000102199 245__ $$aChallenges and recommendations for magnetic hyperthermia characterization measurements
000102199 260__ $$c2021
000102199 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102199 5203_ $$aPurpose: The localized heating of magnetic nanoparticles (MNPs) via the application of time-varying magnetic fields–a process known as magnetic field hyperthermia (MFH)–can greatly enhance existing options for cancer treatment; but for broad clinical uptake its optimization, reproducibility and safety must be comprehensively proven. As part of this effort, the quantification of MNP heating–characterized by the specific loss power (SLP), measured in W/g, or by the intrinsic loss power (ILP), in Hm2/kg–is frequently reported. However, in SLP/ILP measurements to date, the apparatus, the analysis techniques and the field conditions used by different researchers have varied greatly, leading to questions as to the reproducibility of the measurements. Materials and Methods: An interlaboratory study (across N = 21 European sites) of calorimetry measurements that constitutes a snapshot of the current state-of-the-art within the MFH community has been undertaken. Identical samples of two stable nanoparticle systems were distributed to all participating laboratories. Raw measurement data as well as the results of in-house analysis techniques were collected along with details of the measurement apparatus used. Raw measurement data was further reanalyzed by universal application of the corrected-slope method to examine relative influences of apparatus and results processing. Results: The data show that although there is very good intralaboratory repeatability, the overall interlaboratory measurement accuracy is poor, with the consolidated ILP data having standard deviations on the mean of ca. ± 30% to ± 40%. There is a strong systematic component to the uncertainties, and a clear rank correlation between the measuring laboratory and the ILP. Both of these are indications of a current lack of normalization in this field. A number of possible sources of systematic uncertainties are identified, and means determined to alleviate or minimize them. However, no single dominant factor was identified, and significant work remains to ascertain and remove the remaining uncertainty sources. Conclusion: We conclude that the study reveals a current lack of harmonization in MFH characterization of MNPs, and highlights the growing need for standardized, quantitative characterization techniques for this emerging medical technology.
000102199 536__ $$9info:eu-repo/grantAgreement/EUR/COST-Action/TD1402-Radiomag$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-85617-R$$9info:eu-repo/grantAgreement/ES/MINECO/MAT2017-86826-R$$9info:eu-repo/grantAgreement/ES/MINECO/RED2018-102626-T$$9info:eu-repo/grantAgreement/ES/MINECO/SEV-2016-0686
000102199 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000102199 590__ $$a3.753$$b2021
000102199 592__ $$a0.709$$b2021
000102199 594__ $$a6.0$$b2021
000102199 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b54 / 136 = 0.397$$c2021$$dQ2$$eT2
000102199 593__ $$aCancer Research$$c2021$$dQ2
000102199 591__ $$aONCOLOGY$$b143 / 245 = 0.584$$c2021$$dQ3$$eT2
000102199 593__ $$aRadiological and Ultrasound Technology$$c2021$$dQ2
000102199 593__ $$aPhysiology$$c2021$$dQ2
000102199 593__ $$aMedicine (miscellaneous)$$c2021$$dQ2
000102199 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000102199 700__ $$aOrtega, D.
000102199 700__ $$aSteinhoff, U.
000102199 700__ $$aDutz, S.
000102199 700__ $$aGaraio, E.
000102199 700__ $$aSandre, O.
000102199 700__ $$0(orcid)0000-0003-2553-0633$$aNatividad, E.$$uUniversidad de Zaragoza
000102199 700__ $$aCruz, M.M.
000102199 700__ $$aBrero, F.
000102199 700__ $$aSouthern, P.
000102199 700__ $$aPankhurst, Q.A.
000102199 700__ $$aSpassov, S.
000102199 700__ $$athe, RADIOMAG, consortium
000102199 7102_ $$15001$$2065$$aUniversidad de Zaragoza$$bDpto. Ciencia Tecnol.Mater.Fl.$$cÁrea Cienc.Mater. Ingen.Metal.
000102199 773__ $$g38, 1 (2021), 447-460$$pInt. j. hypertherm.$$tINTERNATIONAL JOURNAL OF HYPERTHERMIA$$x0265-6736
000102199 8564_ $$s2998930$$uhttps://zaguan.unizar.es/record/102199/files/texto_completo.pdf$$yVersión publicada
000102199 8564_ $$s1177052$$uhttps://zaguan.unizar.es/record/102199/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000102199 909CO $$ooai:zaguan.unizar.es:102199$$particulos$$pdriver
000102199 951__ $$a2023-05-18-14:52:47
000102199 980__ $$aARTICLE