000102240 001__ 102240
000102240 005__ 20210902121801.0
000102240 0247_ $$2doi$$a10.1016/j.semarthrit.2020.05.016
000102240 0248_ $$2sideral$$a118127
000102240 037__ $$aART-2020-118127
000102240 041__ $$aeng
000102240 100__ $$aTorrente-Segarra, V.
000102240 245__ $$aAssociated factors to serious infections in a large cohort of juvenile-onset systemic lupus erythematosus from Lupus Registry (RELESSER).
000102240 260__ $$c2020
000102240 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102240 5203_ $$aObjective: To assess the incidence of serious infection (SI) and associated factors in a large juvenile-onset systemic lupus erythematosus (jSLE) retrospective cohort. Methods: All patients in the Spanish Rheumatology Society Lupus Registry (RELESSER) who meet =4 ACR-97 SLE criteria and disease onset <18 years old (jSLE), were retrospectively investigated for SI (defined as either the need for hospitalization with antibacterial therapy for a potentially fatal infection or death caused by the infection). Standardized SI rate was calculated per 100 patient years. Patients with and without SI were compared. Bivariate and multivariate logistic and Cox regression models were built to calculate associated factors to SI and relative risks. Results: A total of 353 jSLE patients were included: 88.7% female, 14.3 years (± 2.9) of age at diagnosis, 16.0 years (± 9.3) of disease duration and 31.5 years (±10.5) at end of follow-up. A total of 104 (29.5%) patients suffered 205 SI (1, 55.8%; 2-5, 38.4%; and =6, 5.8%). Incidence rate was 3.7 (95%CI: 3.2–4.2) SI per 100 patient years. Respiratory location and bacterial infections were the most frequent. Higher number of SLE classification criteria, SLICC/ACR DI score and immunosuppressants use were associated to the presence of SI. Associated factors to shorter time to first infection were higher number of SLE criteria, splenectomy and immunosuppressants use. Conclusions: The risk of SI in jSLE patients is significant and higher than aSLE. It is associated to higher number of SLE criteria, damage accrual, some immunosuppressants and splenectomy.
000102240 536__ $$9info:eu-repo/grantAgreement/EC/FP7/316265/EU/BIOMEDICAL CAPACITIES SUPPORT PROGRAM/BIOCAPS$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER-FIS/PI11-02857
000102240 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000102240 590__ $$a5.532$$b2020
000102240 591__ $$aRHEUMATOLOGY$$b7 / 34 = 0.206$$c2020$$dQ1$$eT1
000102240 592__ $$a1.955$$b2020
000102240 593__ $$aRheumatology$$c2020$$dQ1
000102240 593__ $$aAnesthesiology and Pain Medicine$$c2020$$dQ1
000102240 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000102240 700__ $$aSalman-Monte, T.C.
000102240 700__ $$aRúa-Figueroa, Í.
000102240 700__ $$adel Campo, V.
000102240 700__ $$aLópez-Longo, F.J.
000102240 700__ $$aGalindo-Izquierdo, M.
000102240 700__ $$aCalvo-Alén, J.
000102240 700__ $$aOlivé-Marqués, A.
000102240 700__ $$aMouriño-Rodríguez, C.
000102240 700__ $$aHorcada, L.
000102240 700__ $$aBohórquez, C.
000102240 700__ $$aMontilla, C.
000102240 700__ $$aSalgado, E.
000102240 700__ $$aDíez-Álvarez, E.
000102240 700__ $$aBlanco, R.
000102240 700__ $$aAndreu, J.L.
000102240 700__ $$aFernández-Berrizbeitia, O.
000102240 700__ $$aExpósito, L.
000102240 700__ $$aGantes, M.
000102240 700__ $$aHernández-Cruz, B.
000102240 700__ $$0(orcid)0000-0002-8458-081X$$aPecondón-Español, Á.$$uUniversidad de Zaragoza
000102240 700__ $$aLozano-Rivas, N.
000102240 700__ $$aBonilla, G.
000102240 700__ $$aLois Iglesias, A.
000102240 700__ $$aRubio-Muñoz, P.
000102240 700__ $$aOvalles, J.
000102240 700__ $$aTomero, E.
000102240 700__ $$aBoteanu, A.
000102240 700__ $$aNarvaez, J.
000102240 700__ $$aFreire, M.
000102240 700__ $$aVela, P.
000102240 700__ $$aQuevedo-Vila, V.
000102240 700__ $$aJuan Mas, A.
000102240 700__ $$aMuñoz-Fernández, S.
000102240 700__ $$aRaya, E.
000102240 700__ $$aMoreno, M.
000102240 700__ $$aVelloso-Feijoo, M.L.
000102240 700__ $$aSoler, G.
000102240 700__ $$aVázquez-Rodríguez, T.R.
000102240 700__ $$aPego-Reigosa, J.M.
000102240 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000102240 773__ $$g50, 4 (2020), 657-662$$pSemin. arthritis rheum.$$tSeminars in Arthritis and Rheumatism$$x0049-0172
000102240 8564_ $$s584916$$uhttps://zaguan.unizar.es/record/102240/files/texto_completo.pdf$$yPostprint
000102240 8564_ $$s2044433$$uhttps://zaguan.unizar.es/record/102240/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
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000102240 951__ $$a2021-09-02-09:55:01
000102240 980__ $$aARTICLE