000102259 001__ 102259 000102259 005__ 20230519145434.0 000102259 0247_ $$2doi$$a10.3390/app11104495 000102259 0248_ $$2sideral$$a124430 000102259 037__ $$aART-2021-124430 000102259 041__ $$aeng 000102259 100__ $$0(orcid)0000-0002-0255-6200$$aNasello , Gabriele 000102259 245__ $$aDesigning Hydrogel-Based Bone-On-Chips for Personalized Medicine 000102259 260__ $$c2021 000102259 5060_ $$aAccess copy available to the general public$$fUnrestricted 000102259 5203_ $$aThe recent development of bone-on-chips (BOCs) holds the main advantage of requiring a low quantity of cells and material, compared to traditional In Vitro models. By incorporating hydrogels within BOCs, the culture system moved to a three dimensional culture environment for cells which is more representative of bone tissue matrix and function. The fundamental components of hydrogel-based BOCs, namely the cellular sources, the hydrogel and the culture chamber, have been tuned to mimic the hematopoietic niche in the bone aspirate marrow, cancer bone metastasis and osteo/chondrogenic differentiation. In this review, we examine the entire process of developing hydrogel-based BOCs to model In Vitro a patient specific situation. First, we provide bone biological understanding for BOCs design and then how hydrogel structural and mechanical properties can be tuned to meet those requirements. This is followed by a review on hydrogel-based BOCs, developed in the last 10 years, in terms of culture chamber design, hydrogel and cell source used. Finally, we provide guidelines for the definition of personalized pathological and physiological bone microenvironments. This review covers the information on bone, hydrogel and BOC that are required to develop personalized therapies for bone disease, by recreating clinically relevant scenarii in miniaturized devices 000102259 536__ $$9info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 722535-CuraBone 000102259 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000102259 590__ $$a2.838$$b2021 000102259 592__ $$a0.507$$b2021 000102259 594__ $$a3.7$$b2021 000102259 591__ $$aENGINEERING, MULTIDISCIPLINARY$$b39 / 92 = 0.424$$c2021$$dQ2$$eT2 000102259 591__ $$aPHYSICS, APPLIED$$b76 / 161 = 0.472$$c2021$$dQ2$$eT2 000102259 591__ $$aMATERIALS SCIENCE, MULTIDISCIPLINARY$$b218 / 345 = 0.632$$c2021$$dQ3$$eT2 000102259 591__ $$aCHEMISTRY, MULTIDISCIPLINARY$$b100 / 180 = 0.556$$c2021$$dQ3$$eT2 000102259 593__ $$aEngineering (miscellaneous)$$c2021$$dQ2 000102259 593__ $$aComputer Science Applications$$c2021$$dQ2 000102259 593__ $$aProcess Chemistry and Technology$$c2021$$dQ2 000102259 593__ $$aMaterials Science (miscellaneous)$$c2021$$dQ2 000102259 593__ $$aFluid Flow and Transfer Processes$$c2021$$dQ2 000102259 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000102259 700__ $$aCóndor , Mar 000102259 700__ $$aVaughan , Ted 000102259 700__ $$aSchiavi , Jessica 000102259 773__ $$g11, 10 (2021), 11104495 [20 pp.]$$pAppl. sci.$$tApplied Sciences (Switzerland)$$x2076-3417 000102259 8564_ $$s3107119$$uhttps://zaguan.unizar.es/record/102259/files/texto_completo.pdf$$yVersión publicada 000102259 8564_ $$s2685549$$uhttps://zaguan.unizar.es/record/102259/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000102259 909CO $$ooai:zaguan.unizar.es:102259$$particulos$$pdriver 000102259 951__ $$a2023-05-18-14:21:01 000102259 980__ $$aARTICLE