000102265 001__ 102265
000102265 005__ 20230519145517.0
000102265 0247_ $$2doi$$a10.3390/ani11040931
000102265 0248_ $$2sideral$$a124058
000102265 037__ $$aART-2021-124058
000102265 041__ $$aeng
000102265 100__ $$0(orcid)0000-0002-1481-9805$$aCequier, A.$$uUniversidad de Zaragoza
000102265 245__ $$aThe usefulness of mesenchymal stem cells beyond the musculoskeletal system in horses
000102265 260__ $$c2021
000102265 5060_ $$aAccess copy available to the general public$$fUnrestricted
000102265 5203_ $$aThe differentiation ability of mesenchymal stem cells (MSCs) initially raised interest for treating musculoskeletal injuries in horses, but MSC paracrine activity has widened their scope for inflammatory and immune-mediated pathologies in both equine and human medicine. Further-more, the similar etiopathogenesis of some diseases in both species has advanced the concept of “One Medicine, One Health”. This article reviews the current knowledge on the use of MSCs for equine pathologies beyond the locomotor system, highlighting the value of the horse as translational model. Ophthalmologic and reproductive disorders are among the most studied for MSC application. Equine asthma, equine metabolic syndrome, and endotoxemia have been less explored but offer an interesting scenario for human translation. The use of MSCs in wounds also provides a potential model for humans because of the healing particularities in both species. High-burden eq-uine-specific pathologies such as laminitis have been suggested to benefit from MSC-therapy, and MSC application in challenging disorders such as neurologic conditions has been proposed. The available data are preliminary, however, and require further development to translate results into the clinic. Nevertheless, current evidence indicates a significant potential of equine MSCs to enlarge their range of application, with particular interest in pathologies analogous to human conditions.
000102265 536__ $$9info:eu-repo/grantAgreement/ES/MINECO/AGL2017-84411-P
000102265 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000102265 590__ $$a3.231$$b2021
000102265 592__ $$a0.61$$b2021
000102265 594__ $$a2.7$$b2021
000102265 591__ $$aVETERINARY SCIENCES$$b16 / 145 = 0.11$$c2021$$dQ1$$eT1
000102265 593__ $$aVeterinary (miscellaneous)$$c2021$$dQ1
000102265 591__ $$aAGRICULTURE, DAIRY & ANIMAL SCIENCE$$b13 / 63 = 0.206$$c2021$$dQ1$$eT1
000102265 593__ $$aAnimal Science and Zoology$$c2021$$dQ1
000102265 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/publishedVersion
000102265 700__ $$aSanz, C.
000102265 700__ $$0(orcid)0000-0003-3289-2675$$aRodellar, C.$$uUniversidad de Zaragoza
000102265 700__ $$0(orcid)0000-0001-9818-508X$$aBarrachina, L.$$uUniversidad de Zaragoza
000102265 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000102265 773__ $$g11, 4 (2021), 931 [28 pp]$$pAnimals (Basel)$$tAnimals$$x2076-2615
000102265 8564_ $$s379759$$uhttps://zaguan.unizar.es/record/102265/files/texto_completo.pdf$$yVersión publicada
000102265 8564_ $$s2672867$$uhttps://zaguan.unizar.es/record/102265/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000102265 909CO $$ooai:zaguan.unizar.es:102265$$particulos$$pdriver
000102265 951__ $$a2023-05-18-15:17:17
000102265 980__ $$aARTICLE