000010400 001__ 10400
000010400 005__ 20190219123653.0
000010400 037__ $$aTESIS-2013-042
000010400 041__ $$aeng
000010400 080__ $$a621:617.5
000010400 1001_ $$aHernández Gascón, Belén
000010400 24500 $$aMechanical modelling of the abdominal wall and biomaterials for hernia surgery
000010400 260__ $$aZaragoza$$bUniversidad de Zaragoza, Prensas de la Universidad$$c2013
000010400 300__ $$a374
000010400 4900_ $$aTesis de la Universidad de Zaragoza$$v2013-24$$x2254-7606
000010400 500__ $$aPresentado:  01 03 2013
000010400 502__ $$aTesis-Univ. Zaragoza, Ingeniería Mecánica, 2013$$bZaragoza, Universidad de Zaragoza$$c2013
000010400 506__ $$aby-nc-nd$$bCreative Commons$$c3.0$$uhttps://creativecommons.org/licenses/by-nc-nd/3.0/
000010400 520__ $$aAbdominal surgery for hernia repair is based on the implantation of a synthetic mesh in the defect area which aims at reinforcing the damaged wall. This clinical intervention is common in today's society and, in unfavorable cases such as obese patients or patients with large defects, could lead to a number of problems that reduce the quality of life of patients. The most common problems are the appearance of fibrosis, the hernia recurrence and occurrence of abdominal discomfort due to poor compliance between the host tissue and the prosthesis. Currently, surgeons have no definitive and universally accepted guidelines for the selection of the appropriate prosthesis for each patient and type of defect. Therefore, the choice of one or another mesh, and their placement in case of anisotropic meshes, is a decision to be taken by the surgeons according to their experience. This thesis aims to study the abdominal hernia surgery from the continuum mechanics point of view. However, for the supply and validation of the generated models, it is necessary to perform an experimental study in an animal model. Since this is a multidisciplinary problem, the study approached was developed in collaboration with the Translational Research Group in Biomaterials and Tissue Engineering at the University of Alcalá de Henares (Madrid). The final goal of hernia surgery is that the prosthesis ensures adequate tissular integration, being capable, among other things, to reproduce the mechanical behaviour of the healthy abdominal wall and to absorb the stresses due to the physiological loads to which the abdomen is subjected. Therefore, in addition to addressing the study in animal models to analyze the integration on the wall, the mechanical modelling of the abdominal wall and the biomaterials used in hernia repair is essential. For this, the construction of an ``in silico'' model of the human abdomen has been developed. Due to the diversity of commercial products on the market, this thesis focusses on the study of three representative prostheses, specifically Surgipro, Optilene and Infinit. These meshes are characterized by different geometric parameters and are made of different materials. In this work, the mechanical properties of the prostheses have been determined experimentally and different constitutive models, that reproduce the patterns of the mechanical behaviour observed in both, the abdominal muscle and implanted biomaterials, have been proposed. Specifically, the numerical modelling of the response of the abdominal muscle, including both active and passive responses, and prostheses have been approached within the framework of the nonlinear hyperelasticity in large deformations. The latter approach of this thesis aims to model, using the finite element method, the mechanical response of the wall with the implanted mesh. A complete model of the human abdomen has been defined from nuclear magnetic resonance imaging. This complete model allows differentiating the main anatomical units of the abdomen and it is used to simulate the passive and active responses. Furthermore, this model allows the study of the response of the healthy wall and the analysis of the final mechanical response of the herniated human abdomen to the placement of different prostheses. In summary, this thesis establishes a methodology to the automation of computational models for personalized surgical procedures in order to select the most appropriate mesh for each patient as well as the appropriate placement on the defect in the case of anisotropic prostheses.
000010400 6531_ $$abiomecánica
000010400 6531_ $$asimulación
000010400 6531_ $$aensayo de materiales
000010400 6531_ $$acirugía abdominal
000010400 700__ $$aCalvo Calzada, Begoña$$edir.
000010400 700__ $$aPeña Baquedano, Estefanía$$edir.
000010400 7102_ $$aUniversidad de Zaragoza$$bIngeniería Mecánica
000010400 8560_ $$fzaguan@unizar.es
000010400 8564_ $$s64949655$$uhttps://zaguan.unizar.es/record/10400/files/TESIS-2013-042.pdf$$zTexto completo (spa)
000010400 909CO $$ooai:zaguan.unizar.es:10400
000010400 909co $$ptesis
000010400 909CO $$pdriver
000010400 9102_ $$aIngeniería mecánica$$bIngeniería Mecánica
000010400 980__ $$aTESIS