000106162 001__ 106162 000106162 005__ 20230519145439.0 000106162 0247_ $$2doi$$a10.1016/j.bone.2021.116032 000106162 0248_ $$2sideral$$a124442 000106162 037__ $$aART-2021-124442 000106162 041__ $$aeng 000106162 100__ $$0(orcid)0000-0002-9864-7683$$aGarcía-Aznar, José Manuel$$uUniversidad de Zaragoza 000106162 245__ $$aMultiscale modeling of bone tissue Mechanobiology 000106162 260__ $$c2021 000106162 5060_ $$aAccess copy available to the general public$$fUnrestricted 000106162 5203_ $$aMechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load-transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration. 000106162 536__ $$9info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone$$9This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 722535-CuraBone$$9info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21$$9info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84780-C2-1-R 000106162 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/ 000106162 590__ $$a4.626$$b2021 000106162 592__ $$a1.086$$b2021 000106162 594__ $$a7.4$$b2021 000106162 591__ $$aENDOCRINOLOGY & METABOLISM$$b60 / 147 = 0.408$$c2021$$dQ2$$eT2 000106162 593__ $$aHistology$$c2021$$dQ1 000106162 593__ $$aEndocrinology, Diabetes and Metabolism$$c2021$$dQ1 000106162 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000106162 700__ $$0(orcid)0000-0002-0255-6200$$aNasello, Gabriele 000106162 700__ $$0(orcid)0000-0001-8324-5596$$aHervas-Raluy, Silvia$$uUniversidad de Zaragoza 000106162 700__ $$0(orcid)0000-0002-2901-4188$$aPérez Ansón, María de los Ángeles$$uUniversidad de Zaragoza 000106162 700__ $$0(orcid)0000-0002-1878-8997$$aGómez-Benito, María José$$uUniversidad de Zaragoza 000106162 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est. 000106162 773__ $$g151, 116032 (2021), [12 pp.]$$pBone$$tBONE$$x8756-3282 000106162 8564_ $$s4030165$$uhttps://zaguan.unizar.es/record/106162/files/texto_completo.pdf$$yVersión publicada 000106162 8564_ $$s2557898$$uhttps://zaguan.unizar.es/record/106162/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000106162 909CO $$ooai:zaguan.unizar.es:106162$$particulos$$pdriver 000106162 951__ $$a2023-05-18-14:28:01 000106162 980__ $$aARTICLE