106162 20230519145439.0 doi 10.1016/j.bone.2021.116032 sideral 124442 ART-2021-124442 eng García-Aznar, José Manuel Universidad de Zaragoza (orcid)0000-0002-9864-7683 Multiscale modeling of bone tissue Mechanobiology 2021 Access copy available to the general public Unrestricted Mechanical environment has a crucial role in our organism at the different levels, ranging from cells to tissues and our own organs. This regulatory role is especially relevant for bones, given their importance as load-transmitting elements that allow the movement of our body as well as the protection of vital organs from load impacts. Therefore bone, as living tissue, is continuously adapting its properties, shape and repairing itself, being the mechanical loads one of the main regulatory stimuli that modulate this adaptive behavior. Here we review some key results of bone mechanobiology from computational models, describing the effect that changes associated to the mechanical environment induce in bone response, implant design and scaffold-driven bone regeneration. info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 722535-CuraBone info:eu-repo/grantAgreement/ES/MICINN/RTI2018-094494-B-C21 info:eu-repo/grantAgreement/ES/MINECO/DPI2017-84780-C2-1-R info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.626 2021 ENDOCRINOLOGY & METABOLISM 60 / 147 = 0.408 2021 Q2 T2 1.086 2021 Histology 2021 Q1 Endocrinology, Diabetes and Metabolism 2021 Q1 7.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Nasello, Gabriele (orcid)0000-0002-0255-6200 Hervas-Raluy, Silvia Universidad de Zaragoza (orcid)0000-0001-8324-5596 Pérez Ansón, María de los Ángeles Universidad de Zaragoza (orcid)0000-0002-2901-4188 Gómez-Benito, María José Universidad de Zaragoza (orcid)0000-0002-1878-8997 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 151, 116032 (2021), [12 pp.] Bone BONE 8756-3282 4030165 http://zaguan.unizar.es/record/106162/files/texto_completo.pdf Versión publicada 2557898 http://zaguan.unizar.es/record/106162/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:106162 articulos driver 2023-05-18-14:28:01 ARTICLE