000106167 001__ 106167
000106167 005__ 20230519145517.0
000106167 0247_ $$2doi$$a10.3390/nu13041077
000106167 0248_ $$2sideral$$a124065
000106167 037__ $$aART-2021-124065
000106167 041__ $$aeng
000106167 100__ $$aPeñalvo, J.L.
000106167 245__ $$aWork shift, lifestyle factors, and subclinical atherosclerosis in spanish male workers: A mediation analysis
000106167 260__ $$c2021
000106167 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106167 5203_ $$a(1) Background: Working night shifts has been associated with altered circadian rhythms, lifestyle habits, and cardiometabolic risks. No information on the potential association of working shift and the presence of atherosclerosis is available. The aim of this study was to quantify the association between different work shifts and the presence of subclinical atherosclerosis objectively measured by imaging. (2) Methods: Analyses were conducted on the baseline data of the Aragon Workers Health Study (AWHS) cohort, including information on 2459 middle-aged men. Categories of shift work included central day shift, rotating morning-evening or morning-evening-night shift, and night shift. The presence of atherosclerotic plaques was assessed by 2D ultrasound in the carotid and femoral vascular territories. Multivariable logistic models and mediation analysis were conducted to characterize and quantify the association between study variables. (3) Results: Participants working night or rotating shifts presented an overall worse cardiometabolic risk profile, as well as more detrimental lifestyle habits. Workers in the most intense (morning-evening-night) rotating shift presented higher odds of subclinical atherosclerosis (odds ratio: 1.6; 95% confidence interval: 1.12 to 2.27) compared to workers in the central shift, independently of the presence of lifestyle and metabolic risk factors. A considerable (21%) proportion of this association was found to be mediated by smoking, indicating that altered sleep-wake cycles have a direct relationship with the early presence of atherosclerotic lesions. (4) Conclusions: Work shifts should be factored in during workers health examinations, and when developing effective workplace wellness programs.
000106167 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00020$$9info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI18-01929
000106167 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000106167 590__ $$a6.706$$b2021
000106167 592__ $$a1.287$$b2021
000106167 594__ $$a7.9$$b2021
000106167 591__ $$aNUTRITION & DIETETICS$$b15 / 90 = 0.167$$c2021$$dQ1$$eT1
000106167 593__ $$aNutrition and Dietetics$$c2021$$dQ1
000106167 593__ $$aFood Science$$c2021$$dQ1
000106167 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000106167 700__ $$aMertens, E.
000106167 700__ $$aMuñoz-Cabrejas, A.
000106167 700__ $$aLeón-Latre, M.
000106167 700__ $$aJarauta, E.
000106167 700__ $$0(orcid)0000-0003-3963-0846$$aLaclaustra, M.$$uUniversidad de Zaragoza
000106167 700__ $$aOrdovás, J.M.
000106167 700__ $$0(orcid)0000-0002-9887-2629$$aCasasnovas, J.A.$$uUniversidad de Zaragoza
000106167 700__ $$aUzhova, I.
000106167 700__ $$0(orcid)0000-0003-0604-5042$$aMoreno-Franco, B.$$uUniversidad de Zaragoza
000106167 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000106167 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000106167 773__ $$g13, 4 (2021), 1077 [13 pp]$$pNutrients$$tNutrients$$x2072-6643
000106167 8564_ $$s322222$$uhttps://zaguan.unizar.es/record/106167/files/texto_completo.pdf$$yVersión publicada
000106167 8564_ $$s2768698$$uhttps://zaguan.unizar.es/record/106167/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000106167 909CO $$ooai:zaguan.unizar.es:106167$$particulos$$pdriver
000106167 951__ $$a2023-05-18-15:17:38
000106167 980__ $$aARTICLE