106167 20230519145517.0 doi 10.3390/nu13041077 sideral 124065 ART-2021-124065 eng Peñalvo, J.L. Work shift, lifestyle factors, and subclinical atherosclerosis in spanish male workers: A mediation analysis 2021 Access copy available to the general public Unrestricted (1) Background: Working night shifts has been associated with altered circadian rhythms, lifestyle habits, and cardiometabolic risks. No information on the potential association of working shift and the presence of atherosclerosis is available. The aim of this study was to quantify the association between different work shifts and the presence of subclinical atherosclerosis objectively measured by imaging. (2) Methods: Analyses were conducted on the baseline data of the Aragon Workers Health Study (AWHS) cohort, including information on 2459 middle-aged men. Categories of shift work included central day shift, rotating morning-evening or morning-evening-night shift, and night shift. The presence of atherosclerotic plaques was assessed by 2D ultrasound in the carotid and femoral vascular territories. Multivariable logistic models and mediation analysis were conducted to characterize and quantify the association between study variables. (3) Results: Participants working night or rotating shifts presented an overall worse cardiometabolic risk profile, as well as more detrimental lifestyle habits. Workers in the most intense (morning-evening-night) rotating shift presented higher odds of subclinical atherosclerosis (odds ratio: 1.6; 95% confidence interval: 1.12 to 2.27) compared to workers in the central shift, independently of the presence of lifestyle and metabolic risk factors. A considerable (21%) proportion of this association was found to be mediated by smoking, indicating that altered sleep-wake cycles have a direct relationship with the early presence of atherosclerotic lesions. (4) Conclusions: Work shifts should be factored in during workers health examinations, and when developing effective workplace wellness programs. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI18-01929 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00020 info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.706 2021 NUTRITION & DIETETICS 15 / 90 = 0.167 2021 Q1 T1 1.287 2021 Nutrition and Dietetics 2021 Q1 Food Science 2021 Q1 7.9 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Mertens, E. Muñoz-Cabrejas, A. León-Latre, M. Jarauta, E. Laclaustra, M. Universidad de Zaragoza (orcid)0000-0003-3963-0846 Ordovás, J.M. Casasnovas, J.A. Universidad de Zaragoza (orcid)0000-0002-9887-2629 Uzhova, I. Moreno-Franco, B. Universidad de Zaragoza (orcid)0000-0003-0604-5042 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 13, 4 (2021), 1077 [13 pp] Nutrients Nutrients 2072-6643 322222 http://zaguan.unizar.es/record/106167/files/texto_completo.pdf Versión publicada 2768698 http://zaguan.unizar.es/record/106167/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:106167 articulos driver 2023-05-18-15:17:38 ARTICLE