000106209 001__ 106209
000106209 005__ 20220425105237.0
000106209 0247_ $$2doi$$a10.1016/j.ijcard.2020.06.009
000106209 0248_ $$2sideral$$a119653
000106209 037__ $$aART-2020-119653
000106209 041__ $$aeng
000106209 100__ $$aValero-Masa, M.J.
000106209 245__ $$aCold ischemia >4 hours increases heart transplantation mortality. An analysis of the Spanish heart transplantation registry
000106209 260__ $$c2020
000106209 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106209 5203_ $$aBackground: Cold ischemia time (CIT) has been associated to heart transplantation (HT) prognosis. However, there is still uncertainty regarding the CIT cutoff value that might have relevant clinical implications.
Methods: We analyzed all adults that received a first HT during the period 2008–2018. CIT was defined as the time between the cross-clamp of the donor aorta and the reperfusion of the heart. Primary outcome was 1-month mortality.
Results: We included 2629 patients, mean age was 53.3 ± 12.1 years and 655 (24.9%) were female. Mean CIT was 202 ± 67 min (minimum 20 min, maximum 600 min). One-month mortality per CIT quartile was 9, 12, 13, and 19%. One-year mortality per CIT quartile was 16, 19, 21, and 28%. CIT was an independent predictor of 1-month mortality, but only in the last quartile of CIT >246 min (odds ratio 2.1, 95% confidence interval 1.49–3.08, p < .001). We found no relevant differences in CIT during the study period. However, the impact of CIT in 1-month and 1-year mortality decreased with time (p value for the distribution of ischemic time by year 0.01), particularly during the last 5 years.
Conclusions: Although the impact of CIT in HT prognosis seems to be decreasing in the last years, CIT in the last quartile (>246 min) is associated with 1-month and 1-year mortality. Our findings suggest the need to limit HT with CIT > 246 min or to use different myocardial preservation systems if the expected CIT is >4 h.
000106209 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000106209 590__ $$a4.164$$b2020
000106209 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b56 / 141 = 0.397$$c2020$$dQ2$$eT2
000106209 592__ $$a1.405$$b2020
000106209 593__ $$aCardiology and Cardiovascular Medicine$$c2020$$dQ1
000106209 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000106209 700__ $$aGonzález-Vílchez, F.
000106209 700__ $$aAlmenar-Bonet, L.
000106209 700__ $$aCrespo-Leiro, M.G.
000106209 700__ $$aManito-Lorite, N.
000106209 700__ $$aSobrino-Márquez, J.M.
000106209 700__ $$aGómez-Bueno, M.
000106209 700__ $$aDelgado-Jiménez, J.F.
000106209 700__ $$aPérez-Villa, F.
000106209 700__ $$aBrossa Loidi, V.
000106209 700__ $$aArizón-el Prado, J.M.
000106209 700__ $$aDíaz Molina, B.
000106209 700__ $$ade la Fuente-Galán, L.
000106209 700__ $$aPortoles Ocampo, A.
000106209 700__ $$aGarrido Bravo, I.P.
000106209 700__ $$aRábago-Juan Aracil, G.
000106209 700__ $$aMartínez-Sellés, M.
000106209 773__ $$g319 (2020), 14-19$$pInt. j. cardiol.$$tINTERNATIONAL JOURNAL OF CARDIOLOGY$$x0167-5273
000106209 8564_ $$s139671$$uhttps://zaguan.unizar.es/record/106209/files/texto_completo.pdf$$yPostprint
000106209 8564_ $$s2430931$$uhttps://zaguan.unizar.es/record/106209/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000106209 909CO $$ooai:zaguan.unizar.es:106209$$particulos$$pdriver
000106209 951__ $$a2022-04-25-10:39:32
000106209 980__ $$aARTICLE