000106219 001__ 106219
000106219 005__ 20221004075859.0
000106219 0247_ $$2doi$$a10.1073/pnas.2015855118
000106219 0248_ $$2sideral$$a124085
000106219 037__ $$aART-2021-124085
000106219 041__ $$aeng
000106219 100__ $$aHawash, M.B.F.
000106219 245__ $$aPrimate innate immune responses to bacterial and viral pathogens reveals an evolutionary trade-off between strength and specificity
000106219 260__ $$c2021
000106219 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106219 5203_ $$aDespite their close genetic relatedness, apes and African and Asian monkeys (AAMs) differ in their susceptibility to severe bacterial and viral infections that are important causes of human disease. Such differences between humans and other primates are thought to be a result, at least in part, of interspecies differences in immune response to infection. However, because of the lack of comparative functional data across species, it remains unclear in what ways the immune systems of humans and other primates differ. Here, we report the whole-genome transcriptomic responses of ape species (human and chimpanzee) and AAMs (rhesus macaque and baboon) to bacterial and viral stimulation. We find stark differences in the responsiveness of these groups, with apes mounting a markedly stronger early transcriptional response to both viral and bacterial stimulation, altering the transcription of ~40% more genes than AAMs. Additionally, we find that genes involved in the regulation of inflammatory and interferon responses show the most divergent early transcriptional responses across primates and that this divergence is attenuated over time. Finally, we find that relative to AAMs, apes engage a much less specific immune response to different classes of pathogens during the early hours of infection, up-regulating genes typical of anti-viral and anti-bacterial responses regardless of the nature of the stimulus. Overall, these findings suggest apes exhibit increased sensitivity to bacterial and viral immune stimulation, activating a broader array of defense molecules that may be beneficial for early pathogen killing at the potential cost of increased energy expenditure and tissue damage. Copyright
000106219 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000106219 590__ $$a12.779$$b2021
000106219 592__ $$a4.184$$b2021
000106219 591__ $$aMULTIDISCIPLINARY SCIENCES$$b9 / 73 = 0.123$$c2021$$dQ1$$eT1
000106219 593__ $$aMultidisciplinary$$c2021$$dQ1
000106219 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000106219 700__ $$0(orcid)0000-0002-7850-8491$$aSanz-Remón, J.$$uUniversidad de Zaragoza
000106219 700__ $$aGrenier, J.C.
000106219 700__ $$aKohn, J.
000106219 700__ $$aYotova, V.
000106219 700__ $$aJohnson, Z.
000106219 700__ $$aLanford, R.E.
000106219 700__ $$aBrinkworth, J.F.
000106219 700__ $$aBarreiro, L.B.
000106219 7102_ $$12004$$2405$$aUniversidad de Zaragoza$$bDpto. Física Teórica$$cÁrea Física Teórica
000106219 773__ $$g118, 13 (2021), e2015855118$$pProc. Natl. Acad. Sci.$$tProceedings of the National Academy of Sciences of the United States of America$$x0027-8424
000106219 8564_ $$s2190630$$uhttps://zaguan.unizar.es/record/106219/files/texto_completo.pdf$$yVersión publicada
000106219 8564_ $$s3807898$$uhttps://zaguan.unizar.es/record/106219/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000106219 909CO $$ooai:zaguan.unizar.es:106219$$particulos$$pdriver
000106219 951__ $$a2022-10-03-14:37:46
000106219 980__ $$aARTICLE