106221 20230519145443.0 doi 10.1016/j.jmbbm.2021.104641 sideral 124461 ART-2021-124461 eng Vautrin, Antoine Time-dependent in silico modelling of orthognathic surgery to support the design of biodegradable bone plates 2021 Access copy available to the general public Unrestricted Orthognathic surgery is performed to realign the jaws of a patient through several osteotomies. The state-of- the-art bone plates used to maintain the bone fragments in place are made of titanium. The presence of these non-degradable plates can have unwanted side effects on the long term (e.g. higher infection risk) if they are not removed. Using a biodegradable material such as magnesium may be a possible solution to this problem. However, biodegradation leads to a decrease of mechanical strength, therefore a time-dependent computational approach can help to evaluate the performance of such plates. In the present work, a computational framework has been developed to include biodegradation and bone healing algorithms in a finite element model. It includes bone plates and the mandible, which are submitted to masticatory loads during the early healing period (two months following the surgery). Two different bone plate designs with different stiffnesses have been tested. The stiff design exhibited good mechanical stability, with maximum Von Mises stress being less than 40% of the yield strength throughout the simulation. The flexible design shows high stresses when the bone healing has not started in the fracture gaps, indicating possible failure of the plate. However, this design leads to a higher bone healing quality after two months, as more cartilage is formed due to higher strains exerted in fracture gaps. We therefore conclude that in silico modelling can support tuning of the design parameters to ensure mechanical stability and while promoting bone healing. info:eu-repo/grantAgreement/EC/H2020/722535/EU/Predictive models and simulations in bone regeneration: a multiscale patient-specific approach/CuraBone This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 722535-CuraBone info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.042 2021 ENGINEERING, BIOMEDICAL 48 / 98 = 0.49 2021 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 27 / 46 = 0.587 2021 Q3 T2 0.746 2021 Biomedical Engineering 2021 Q2 Biomaterials 2021 Q2 6.6 2021 info:eu-repo/semantics/article Wesseling, Mariska Wirix-Speetjens, Roel Gómez Benito, María José Universidad de Zaragoza (orcid)0000-0002-1878-8997 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 121 (2021), 104641 J. mech. behav. boomed. mater. Journal of the Mechanical Behavior of Biomedical Materials 1751-6161 1930449 http://zaguan.unizar.es/record/106221/files/texto_completo.pdf 2791431 http://zaguan.unizar.es/record/106221/files/texto_completo.jpg?subformat=icon icon oai:zaguan.unizar.es:106221 articulos driver 2023-05-18-14:35:25 ARTICLE