000106252 001__ 106252 000106252 005__ 20230622083316.0 000106252 0247_ $$2doi$$a10.1016/j.coemr.2020.06.006 000106252 0248_ $$2sideral$$a119880 000106252 037__ $$aART-2020-119880 000106252 041__ $$aeng 000106252 100__ $$aAguilar-Gomez, F.J. 000106252 245__ $$aMetabolic syndrome before puberty: Myth or reality? 000106252 260__ $$c2020 000106252 5060_ $$aAccess copy available to the general public$$fUnrestricted 000106252 5203_ $$aMetabolic syndrome (MetS) is defined as a cluster of alterations related with insulin resistance (obesity, dyslipidemia, hypertension, and impaired glucose metabolism), which are associated with a higher risk of cardiovascular disease in adults. Several definitions have been proposed for older children and adolescents. However, no definitions have been made in accordance with pubertal status, and those in prepubertal state have not received attention enough, despite there are data suggesting the early presence of risk factors. The new insights concerning healthy and unhealthy metabolic status or the addition of novel metabolic risk biomarkers, may contribute to the knowledge about the development of MetS in children. This manuscript reviews the available evidence on MetS during childhood, focusing on the prepubertal period. 000106252 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI051968$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI11-02042$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/PI16-00871$$9info:eu-repo/grantAgreement/ES/ISCIII/RETICS-RD12-0026-0015 000106252 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/ 000106252 592__ $$a0.264$$b2020 000106252 593__ $$aEndocrinology, Diabetes and Metabolism$$c2020$$dQ3 000106252 655_4 $$ainfo:eu-repo/semantics/review$$vinfo:eu-repo/semantics/acceptedVersion 000106252 700__ $$0(orcid)0000-0002-0902-387X$$aBueno-Lozano, G.$$uUniversidad de Zaragoza 000106252 700__ $$aLeis, R. 000106252 700__ $$aAguilera, C.M. 000106252 700__ $$aGil-Campos, M. 000106252 7102_ $$11011$$2670$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Pediatría 000106252 773__ $$g14 (2020), 97-103$$tCurrent Opinion in Endocrine and Metabolic Research$$x2451-9650 000106252 8564_ $$s108673$$uhttps://zaguan.unizar.es/record/106252/files/texto_completo.pdf$$yPostprint 000106252 8564_ $$s942216$$uhttps://zaguan.unizar.es/record/106252/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint 000106252 909CO $$ooai:zaguan.unizar.es:106252$$particulos$$pdriver 000106252 951__ $$a2023-06-21-15:02:12 000106252 980__ $$aARTICLE