000106253 001__ 106253
000106253 005__ 20230519145355.0
000106253 0247_ $$2doi$$a10.1016/j.arbres.2020.05.034
000106253 0248_ $$2sideral$$a119955
000106253 037__ $$aART-2021-119955
000106253 041__ $$aspa
000106253 100__ $$0(orcid)0000-0003-3670-2664$$aBello, S.$$uUniversidad de Zaragoza
000106253 245__ $$aNúcleo de microbiota en el cáncer de pulmón central con enriquecimiento estreptocócico como posible marcador de diagnóstico
000106253 260__ $$c2021
000106253 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106253 5203_ $$aBackground: Dysbiosis in lung cancer has been underexplored. The aim of this study was to define the bacterial and fungal microbiota of the bronchi in central lung cancer and to compare it with that of the oral and intestinal compartments.
Methods: Twenty-five patients with central lung cancer and sixteen controls without antimicrobial intake during the previous month were recruited. Bacterial and fungal distribution was determined by massive sequencing of bronchial biopsies and saliva and faecal samples. Complex computational analysis was performed to define the core lung microbiota.
Results: Affected and contralateral bronchi of patients have almost identical microbiota dominated by Streptococcus, whereas Pseudomonas was the dominant genera in controls. Oral and pulmonary ecosystems were significantly more similar in patients, probably due to microaspirations. Streptococcal abundance in the bronchi differentiated patients from controls according to a ROC curve analysis (90.9% sensitivity, 83.3% specificity, AUC = 0.897). The saliva of patients characteristically showed a greater abundance of Streptococcus, Rothia, Gemella and Lactobacillus. The mycobiome of controls (Candida) was significantly different from that of patients (Malassezia). Cancer patients’ bronchial mycobiome was similar to their saliva, but different from their contralateral bronchi.
Conclusions: The central lung cancer microbiome shows high levels of Streptococcus, and differs significantly in its composition from that of control subjects. Changes are not restricted to tumour tissue, and seem to be the consequence of microaspirations from the oral cavity. These findings could be useful in the screening and even diagnosis of this disease.
000106253 536__ $$9info:eu-repo/grantAgreement/ES/ESF-ERDF/PEJD-2018-PRE-BMD-8237$$9info:eu-repo/grantAgreement/ES/ISCIII/CM19-00069$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-00115
000106253 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000106253 590__ $$a6.333$$b2021
000106253 591__ $$aRESPIRATORY SYSTEM$$b14 / 66 = 0.212$$c2021$$dQ1$$eT1
000106253 594__ $$a2.0$$b2021
000106253 592__ $$a0.262$$b2021
000106253 593__ $$aPulmonary and Respiratory Medicine$$c2021$$dQ3
000106253 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000106253 700__ $$aVengoechea, J.J.
000106253 700__ $$aPonce-Alonso, M.
000106253 700__ $$aFigueredo, A.L.
000106253 700__ $$aMincholé, E.
000106253 700__ $$0(orcid)0000-0001-7294-245X$$aRezusta, A.$$uUniversidad de Zaragoza
000106253 700__ $$aGambó, P.
000106253 700__ $$aPastor, J.M.
000106253 700__ $$aJavier, Galeano
000106253 700__ $$adel Campo, R.
000106253 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000106253 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000106253 773__ $$g57, 11 (2021), 681-689$$pArch. bronconeumol.$$tArchivos de Bronconeumologia$$x0300-2896
000106253 8564_ $$s548912$$uhttps://zaguan.unizar.es/record/106253/files/texto_completo.pdf$$yPostprint
000106253 8564_ $$s2435316$$uhttps://zaguan.unizar.es/record/106253/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000106253 909CO $$ooai:zaguan.unizar.es:106253$$particulos$$pdriver
000106253 951__ $$a2023-05-18-13:32:07
000106253 980__ $$aARTICLE