000106603 001__ 106603
000106603 005__ 20210902121732.0
000106603 0247_ $$2doi$$a10.1016/j.vaccine.2020.07.062
000106603 0248_ $$2sideral$$a119651
000106603 037__ $$aART-2020-119651
000106603 041__ $$aeng
000106603 100__ $$aContreras, M.
000106603 245__ $$aControl of tick infestations in wild roe deer (Capreolus capreolus) vaccinated with the Q38 Subolesin/Akirin chimera
000106603 260__ $$c2020
000106603 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106603 5203_ $$aTicks (Acari: Ixodidae) are considered to be the most important vectors of disease-causing pathogens in domestic and wild animals, and emerging and re-emerging tick-borne diseases (TBD) exert an enormous impact on them. Wild ungulates are hosts for a wide variety of tick species and tick-borne pathogens that affect human and animal health. Consequently, the control of tick infestations and tick-borne pathogen prevalence is essential in some regions. Acaricides and animal management or culling have been used for the control of tick infestations and TBD, but tick vaccines constitute the best alternative to reduce the impact of acaricides on tick resistance and the environment. Previous results of controlled vaccination trials have shown that the Q38 Subolesin/Akirin chimera containing conserved protective epitopes could be a candidate universal antigen to control multiple tick species infestations. Thus, vaccination trials are necessary to validate these results under field conditions. In this study, we characterized the effect of Q38 vaccine on a wild population of European roe deer (Capreolus capreolus) in the Andalusian roe deer Reference Station (Junta de Andalucía, Cádiz, Spain). In this location, roe deer suffer especially severe parasitic conditions in some periods and commercial pesticides and ixodicides that are authorized to control ticks without specificity are frequently applied in the field, posing a threat to the environment. Animals vaccinated over a three-year period showed an antibody response to the vaccine antigen and a reduction in tick infestations by multiple species including Hyalomma marginatum, H. lusitanicum, Rhipicephalus bursa and Ixodes ricinus previously identified in roe deer, when compared to untreated controls. These results suggest the efficacy of Q38 for the control of tick infestations in wildlife.
000106603 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000106603 590__ $$a3.641$$b2020
000106603 591__ $$aMEDICINE, RESEARCH & EXPERIMENTAL$$b76 / 140 = 0.543$$c2020$$dQ3$$eT2
000106603 591__ $$aIMMUNOLOGY$$b99 / 162 = 0.611$$c2020$$dQ3$$eT2
000106603 592__ $$a1.585$$b2020
000106603 593__ $$aInfectious Diseases$$c2020$$dQ1
000106603 593__ $$aVeterinary (miscellaneous)$$c2020$$dQ1
000106603 593__ $$aPublic Health, Environmental and Occupational Health$$c2020$$dQ1
000106603 593__ $$aMolecular Medicine$$c2020$$dQ1
000106603 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000106603 700__ $$aSan José, C.
000106603 700__ $$0(orcid)0000-0001-7483-046X$$aEstrada-Peña, A.$$uUniversidad de Zaragoza
000106603 700__ $$aTalavera, V.
000106603 700__ $$aRayas, E.
000106603 700__ $$aIsabel León, C.
000106603 700__ $$aLuis Núñez, J.
000106603 700__ $$aGarcía Fernández de Mera, I.
000106603 700__ $$ade la Fuente, J.
000106603 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000106603 773__ $$g28, 41 (2020), 6450-6454$$pVaccine$$tVACCINE$$x0264-410X
000106603 8564_ $$s455544$$uhttps://zaguan.unizar.es/record/106603/files/texto_completo.pdf$$yPostprint
000106603 8564_ $$s2889144$$uhttps://zaguan.unizar.es/record/106603/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000106603 909CO $$ooai:zaguan.unizar.es:106603$$particulos$$pdriver
000106603 951__ $$a2021-09-02-09:36:29
000106603 980__ $$aARTICLE