000106624 001__ 106624
000106624 005__ 20220426091144.0
000106624 0247_ $$2doi$$a10.1016/j.archger.2020.104112
000106624 0248_ $$2sideral$$a119865
000106624 037__ $$aART-2020-119865
000106624 041__ $$aeng
000106624 100__ $$aMakkar, S.R.
000106624 245__ $$aEducation and the moderating roles of age, sex, ethnicity and apolipoprotein epsilon 4 on the risk of cognitive impairment
000106624 260__ $$c2020
000106624 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106624 5203_ $$aBackground: We examined how the relationship between education and latelife cognitive impairment (defined as a Mini Mental State Examination score below 24) is influenced by age, sex, ethnicity, and Apolipoprotein E epsilon 4 (APOE*4).
Methods: Participants were 30, 785 dementia-free individuals aged 55–103 years, from 18 longitudinal cohort studies, with an average follow-up ranging between 2 and 10 years. Pooled hazard ratios were obtained from multilevel parametric survival analyses predicting cognitive impairment (CI) from education and its interactions with baseline age, sex, APOE*4 and ethnicity. In separate models, education was treated as continuous (years) and categorical, with participants assigned to one of four education completion levels: Incomplete Elementary; Elementary; Middle; and High School.
Results: Compared to Elementary, Middle (HR = 0.645, P = 0.004) and High School (HR = 0.472, P < 0.001) education were related to reduced CI risk. The decreased risk of CI associated with Middle education weakened with older baseline age (HR = 1.029, P = 0.056) and was stronger in women than men (HR = 1.309, P = 0.001). The association between High School and lowered CI risk, however, was not moderated by sex or baseline age, but was stronger in Asians than Whites (HR = 1.047, P = 0.044), and significant among Asian (HR = 0.34, P < 0.001) and Black (HR = 0.382, P = 0.016), but not White, APOE*4 carriers.
Conclusion: High School completion may reduce risk of CI associated with advancing age and APOE*4. The observed ethnoregional differences in this effect are potentially due to variations in social, economic, and political outcomes associated with educational attainment, in combination with neurobiological and genetic differences, and warrant further study.
000106624 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Group 19$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/G03-128$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/01-0255$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/03-0815$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/06-0617$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/94-1562$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/97-1321E$$9info:eu-repo/grantAgreement/ES/MINECO-ISCIII/FIS/98-0103
000106624 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000106624 590__ $$a3.25$$b2020
000106624 591__ $$aGERIATRICS & GERONTOLOGY$$b34 / 53 = 0.642$$c2020$$dQ3$$eT2
000106624 592__ $$a0.984$$b2020
000106624 593__ $$aAging$$c2020$$dQ1
000106624 593__ $$aHealth (social science)$$c2020$$dQ1
000106624 593__ $$aGerontology$$c2020$$dQ1
000106624 593__ $$aGeriatrics and Gerontology$$c2020$$dQ1
000106624 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000106624 700__ $$aLipnicki, D.M.
000106624 700__ $$aCrawford, J.D.
000106624 700__ $$aKochan, N.A.
000106624 700__ $$aCastro-Costa, E.
000106624 700__ $$aLima-Costa, M.F.
000106624 700__ $$aDiniz, B.S.
000106624 700__ $$aBrayne, C.
000106624 700__ $$aStephan, B.
000106624 700__ $$aMatthews, F.
000106624 700__ $$aLlibre-Rodriguez, J.J.
000106624 700__ $$aLlibre-Guerra, J.J.
000106624 700__ $$aValhuerdi-Cepero, A.J.
000106624 700__ $$aLipton, R.B.
000106624 700__ $$aKatz, M.J.
000106624 700__ $$aZammit, A.
000106624 700__ $$aRitchie, K.
000106624 700__ $$aCarles, S.
000106624 700__ $$aCarriere, I.
000106624 700__ $$aScarmeas, N.
000106624 700__ $$aYannakoulia, M.
000106624 700__ $$aKosmidis, M.
000106624 700__ $$aLam, L.
000106624 700__ $$aFung, A.
000106624 700__ $$aChan, W.C.
000106624 700__ $$aGuaita, A.
000106624 700__ $$aVaccaro, R.
000106624 700__ $$aDavin, A.
000106624 700__ $$aKim, K.W.
000106624 700__ $$aHan, J.W.
000106624 700__ $$aSuh, S.W.
000106624 700__ $$aRiedel-Heller, S.G.
000106624 700__ $$aRoehr, S.
000106624 700__ $$aPabst, A.
000106624 700__ $$aGanguli, M.
000106624 700__ $$aHughes, T.F.
000106624 700__ $$aJacobsen, E.P.
000106624 700__ $$aAnstey, K.J.
000106624 700__ $$aCherbuin, N.
000106624 700__ $$aHaan, M.N.
000106624 700__ $$aAiello, A.E.
000106624 700__ $$aDang, K.
000106624 700__ $$aKumagai, S.
000106624 700__ $$aNarazaki, K.
000106624 700__ $$aChen, S.
000106624 700__ $$aNg, T.P.
000106624 700__ $$aGao, Q.
000106624 700__ $$aNyunt, M.S.Z.
000106624 700__ $$aMeguro, K.
000106624 700__ $$aYamaguchi, S.
000106624 700__ $$aIshii, H.
000106624 700__ $$aLobo, A.
000106624 700__ $$0(orcid)0000-0002-1252-2397$$aLobo Escolar, E.$$uUniversidad de Zaragoza
000106624 700__ $$0(orcid)0000-0003-2284-7862$$aDe la Cámara, C.$$uUniversidad de Zaragoza
000106624 700__ $$aBrodaty, H.
000106624 700__ $$aTrollor, J.N.
000106624 700__ $$aLeung, Y.
000106624 700__ $$aLo, J.W.
000106624 700__ $$aSachdev, P.
000106624 700__ $$afor, Cohort, Studies, of, Memory, in, an, International, Consortium, (COSMIC)
000106624 7102_ $$11007$$2745$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Psiquiatría
000106624 7102_ $$11011$$2615$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Medic.Prevent.Salud Públ.
000106624 773__ $$g91, 104112 (2020), [11 pp]$$pArch. gerontol. geriatr.$$tARCHIVES OF GERONTOLOGY AND GERIATRICS$$x0167-4943
000106624 8564_ $$s321933$$uhttps://zaguan.unizar.es/record/106624/files/texto_completo.pdf$$yPostprint
000106624 8564_ $$s1673949$$uhttps://zaguan.unizar.es/record/106624/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000106624 909CO $$ooai:zaguan.unizar.es:106624$$particulos$$pdriver
000106624 951__ $$a2022-04-26-08:59:00
000106624 980__ $$aARTICLE