106627 20220426091142.0 doi 10.1002/smll.202000269 sideral 119882 ART-2020-119882 eng Chiodini, Stefano Universidad de Zaragoza (orcid)0000-0002-8842-9324 Bottom Effect in Atomic Force Microscopy Nanomechanics 2020 Access copy available to the general public Unrestricted In this work, the influence of the rigid substrate on the determination of the sample Young''s modulus, the so-called bottom-effect artifact, is demonstrated by an atomic force microscopy force-spectroscopy experiment. The nanomechanical properties of a one-component supported lipid membrane (SLM) exhibiting areas of two different thicknesses are studied: While a standard contact mechanics model (Sneddon) provides two different elastic moduli for these two morphologies, it is shown that Garcia''s bottom-effect artifact correction yields a unique value, as expected for an intrinsic material property. Remarkably, it is demonstrated that the ratio between the contact radius (and not only the indentation) and the sample thickness is the key parameter addressing the relevance of the bottom-effect artifact. The experimental results are validated by finite element method simulations providing a solid support to Garcia''s theory. The amphiphilic nature of the investigated material is representative of several kinds of lipids, suggesting that the results have far reaching implications for determining the correct Young''s modulus of SLMs. The generality of Garcia''s bottom-effect artifact correction allows its application to every kind of supported soft film. info:eu-repo/grantAgreement/ES/DGA-FEDER/E31-17R info:eu-repo/grantAgreement/EUR/ERA-NET-COFUND/MagicCellGene Project 2016 info:eu-repo/grantAgreement/ES/MINECO/PCIN-2017-127 info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 13.281 2020 CHEMISTRY, PHYSICAL 14 / 162 = 0.086 2020 Q1 T1 MATERIALS SCIENCE, MULTIDISCIPLINARY 25 / 333 = 0.075 2020 Q1 T1 NANOSCIENCE & NANOTECHNOLOGY 13 / 106 = 0.123 2020 Q1 T1 PHYSICS, CONDENSED MATTER 7 / 69 = 0.101 2020 Q1 T1 CHEMISTRY, MULTIDISCIPLINARY 18 / 178 = 0.101 2020 Q1 T1 PHYSICS, APPLIED 11 / 160 = 0.069 2020 Q1 T1 3.785 2020 Biomaterials 2020 Q1 Biotechnology 2020 Q1 Chemistry (miscellaneous) 2020 Q1 Nanoscience and Nanotechnology 2020 Q1 Materials Science (miscellaneous) 2020 Q1 Medicine (miscellaneous) 2020 Q1 Engineering (miscellaneous) 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Ruiz-Rincón, Silvia Garcia, P.D. Martin, Santiago Universidad de Zaragoza (orcid)0000-0001-9193-3874 Kettelhoit, K. Armenia, I. Werz, D.B. Cea, Pilar Universidad de Zaragoza (orcid)0000-0002-4729-9578 2012 755 Universidad de Zaragoza Dpto. Química Física Área Química Física 16, 35 (2020), 2000269 [8 pp] Small Small 1613-6810 2399133 http://zaguan.unizar.es/record/106627/files/texto_completo.pdf Postprint 1017270 http://zaguan.unizar.es/record/106627/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:106627 articulos driver 2022-04-26-08:57:42 ARTICLE