000106630 001__ 106630
000106630 005__ 20220426091140.0
000106630 0247_ $$2doi$$a10.1016/j.rmed.2020.106105
000106630 0248_ $$2sideral$$a119896
000106630 037__ $$aART-2020-119896
000106630 041__ $$aeng
000106630 100__ $$aPerez, T.A.
000106630 245__ $$aSex differences between women and men with COPD: A new analysis of the 3CIA study
000106630 260__ $$c2020
000106630 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106630 5203_ $$aBackground: There is partial evidence that COPD is expressed differently in women than in men, namely on symptoms, pulmonary function, exacerbations, comorbidities or prognosis. There is a need to improve the characterization of COPD in females.
Methods: We obtained and pooled data of 17 139 patients from 22 COPD cohorts and analysed the clinical differences by sex, establishing the relationship between these characteristics in women and the prognosis and severity of the disease. Comparisons were established with standard statistics and survival analysis, including crude and multivariate Cox-regression analysis.
Results: Overall, 5355 (31.2%) women were compared with men with COPD. Women were younger, had lower pack-years, greater FEV1%, lower BMI and a greater number of exacerbations (all p < 0.05). On symptoms, women reported more dyspnea, equal cough but less expectoration (p < 0.001). There were no differences in the BODE index score in women (2.4) versus men (2.4) (p = 0.5), but the distribution of all BODE components was highly variable by sex within different thresholds of BODE. On prognosis, 5-year survival was higher in COPD females (86.9%) than in males (76.3%), p < 0.001, in all patients and within each of the specific comorbidities that we assessed. The crude and adjusted RR and 95% C.I. for death in males was 1.82 (1.69–1.96) and 1.73 (1.50–2.00), respectively.
Conclusions: COPD in women has some characteristic traits expressed differently than compared to men, mainly with more dyspnea and COPD exacerbations and less phlegm, among others, although long-term survival appears better in female COPD patients.
000106630 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000106630 590__ $$a3.415$$b2020
000106630 591__ $$aRESPIRATORY SYSTEM$$b27 / 64 = 0.422$$c2020$$dQ2$$eT2
000106630 591__ $$aCARDIAC & CARDIOVASCULAR SYSTEMS$$b64 / 141 = 0.454$$c2020$$dQ2$$eT2
000106630 592__ $$a1.316$$b2020
000106630 593__ $$aPulmonary and Respiratory Medicine$$c2020$$dQ1
000106630 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000106630 700__ $$aCastillo, E.G.
000106630 700__ $$aAncochea, J.
000106630 700__ $$aPastor Sanz, M.T.
000106630 700__ $$aAlmagro, P.
000106630 700__ $$aMartínez-Camblor, P.
000106630 700__ $$aMiravitlles, M.
000106630 700__ $$aRodríguez-Carballeira, M.
000106630 700__ $$aNavarro, A.
000106630 700__ $$aLamprecht, B.
000106630 700__ $$aRamírez-García Luna, A.S.
000106630 700__ $$aKaiser, B.
000106630 700__ $$aAlfageme, I.
000106630 700__ $$aCasanova, C.
000106630 700__ $$aEsteban, C.
000106630 700__ $$aSoler-Cataluña, J.J.
000106630 700__ $$aDe-Torres, J.P.
000106630 700__ $$aCelli, B.R.
000106630 700__ $$0(orcid)0000-0001-9096-2294$$aMarin, J.M.$$uUniversidad de Zaragoza
000106630 700__ $$aLopez-Campos, J.L.
000106630 700__ $$aRiet, G.T.
000106630 700__ $$aSobradillo, P.
000106630 700__ $$aLange, P.
000106630 700__ $$aGarcia-Aymerich, J.
000106630 700__ $$aAnto, J.M.
000106630 700__ $$aTurner, A.M.
000106630 700__ $$aHan, M.K.
000106630 700__ $$aLanghammer, A.
000106630 700__ $$aSternberg, A.
000106630 700__ $$aLeivseth, L.
000106630 700__ $$aBakke, P.
000106630 700__ $$aJohannessen, A.
000106630 700__ $$aOga, T.
000106630 700__ $$aCosío, B.
000106630 700__ $$aEchazarreta, A.
000106630 700__ $$aRoche, N.
000106630 700__ $$aBurgel, P.R.
000106630 700__ $$aSin, D.D.
000106630 700__ $$aPuhan, M.A.
000106630 700__ $$aSoriano, J.B.
000106630 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000106630 773__ $$g171, 106105 (2020), [7 pp.]$$pRespir. med.$$tRespiratory Medicine$$x0954-6111
000106630 8564_ $$s225637$$uhttps://zaguan.unizar.es/record/106630/files/texto_completo.pdf$$yPostprint
000106630 8564_ $$s1412997$$uhttps://zaguan.unizar.es/record/106630/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000106630 909CO $$ooai:zaguan.unizar.es:106630$$particulos$$pdriver
000106630 951__ $$a2022-04-26-08:56:15
000106630 980__ $$aARTICLE