doi:10.1021/acsami.0c06725engLafuente, M.Pellejero, I.Clemente, A.Urbiztondo, M.A.Mallada, R.Reinoso, S.Pina, M.P.Gandía, L.M.In Situ Synthesis of SERS-Active Au@POM Nanostructures in a Microfluidic Device for Real-Time Detection of Water PollutantsART-2020-119899We present a simple, versatile, and low-cost approach for the preparation of surface-enhanced Raman spectroscopy (SERS)-active regions within a microfluidic channel 50 cm in length. The approach involves the UV-light-driven formation of polyoxometalate-decorated gold nanostructures, Au@POM (POM: H3PW12O40 (PW) and H3PMo12O40 (PMo)), that self-assemble in situ on the surface of the polydimethylsiloxane (PDMS) microchannels without any extra functionalization procedure. The fabricated LoCs were characterized by scanning electron microscopy (SEM), UV-vis, Raman, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS) techniques. The SERS activity of the resulting Au@POM-coated lab-on-a-chip (LoC) devices was evaluated in both static and flow conditions using rhodamine R6G. The SERS response of Au@PW-based LoCs was found to be superior to Au@PMo counterparts and outstanding when compared to reported data on metal@POM nanocomposites. We demonstrate the potentialities of both Au@POM-coated LoCs as analytical platforms for real-time detection of the organophosphorous pesticide paraoxon-methyl at 10-6 M concentration level.2020http://zaguan.unizar.es/record/10663210.1021/acsami.0c06725http://zaguan.unizar.es/record/106632oai:zaguan.unizar.es:106632info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-79419-RACS Applied Materials and Interfaces 12, 32 (2020), 36458-36467All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess