Prediction of late-onset small for gestational age and fetal growth restriction by fetal biometry at 35 weeks and impact of ultrasound–delivery interval: comparison of six fetal growth standards

Savirón-Cornudella, Ricardo (Universidad de Zaragoza) ; Esteban, Luis Mariano ; Aznar-Gimeno, Rocio ; Dieste-Pérez, Peña (Universidad de Zaragoza) ; Pérez-López, Faustino R. ; Campillos, Jose M. (Universidad de Zaragoza) ; Castán-Larraz, Beatriz ; Sanz, Gerardo (Universidad de Zaragoza) ; Tajada-Duaso, Mauricio (Universidad de Zaragoza)

Resumen: Small-for-gestational-age (SGA) infants have been associated with increased risk of adverse perinatal outcomes (APOs). In this work, we assess the predictive ability of the ultrasound-estimated percentile weight (EPW) at 35 weeks of gestational age to predict late-onset SGA and APOs, according to six growth standards, and whether the ultrasound–delivery interval influences the detection rate. To this purpose, we analyze a retrospective cohort study of 9585 singleton pregnancies. EPWs at 35 weeks were calculated to the customized Miguel Servet University Hospital (MSUH) and Figueras standards and the non-customized MSUH, Fetal Medicine Foundation (FMF), INTERGROWTH-21st, and WHO standards. As results of our analysis, for a 10% false positive rate, the detection rates for SGA ranged between 48.9% with the customized Figueras standard (AUC 0.82) and 60.8% with the non-customized FMF standard (AUC 0.87). Detection rates to predict SGA by ultrasound–delivery interval (1–6 weeks) show higher detection rates as intervals decrease. APOs detection rates ranged from 27.0% with FMF to 7.9% with the Figueras standard. In conclusion, the ability of EPW to predict SGA at 35 weeks is good for all standards, and slightly better for non-customized standards. The APO detection rate is significantly greater for non-customized standards.

Idioma: Inglés

DOI: 10.3390/jcm10132984

Año: 2021

Publicado en: Journal of Clinical Medicine 10, 13 (2021), 2984 [17 pp.]
ISSN: 2077-0383

Factor impacto JCR: 4.964 (2021)

Categ. JCR: MEDICINE, GENERAL & INTERNAL rank: 55 / 172 = 0.32 (2021) - Q2 - T1

Factor impacto CITESCORE: 4.4 - Medicine (Q2)

Factor impacto SCIMAGO: 1.04 - Medicine (miscellaneous) (Q1)

Financiación: info:eu-repo/grantAgreement/ES/MINECO/MTM2017-83812-P

Tipo y forma: Artículo (Versión definitiva)

Área (Departamento): Área Estadís. Investig. Opera. (Dpto. Métodos Estadísticos)
Área (Departamento): Area Anatom.Embriol.Humana (Dpto. Anatom.Histolog.Humanas)
Área (Departamento): Área Obstetricia y Ginecología (Dpto. Cirugía)