000106733 001__ 106733
000106733 005__ 20230519145411.0
000106733 0247_ $$2doi$$a10.3390/antibiotics10070762
000106733 0248_ $$2sideral$$a124549
000106733 037__ $$aART-2021-124549
000106733 041__ $$aeng
000106733 100__ $$0(orcid)0000-0003-3850-9833$$aSerrano Andrés, María Jesús
000106733 245__ $$aAntibacterial residue excretion via urine as an indicator for therapeutical treatment choice and farm waste treatment
000106733 260__ $$c2021
000106733 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106733 5203_ $$aMany of the infectious diseases that affect livestock have bacteria as etiological agents. Thus, therapy is based on antimicrobials that leave the animal’s tissues mainly via urine, reaching the environment through slurry and waste water. Once there, antimicrobial residues may lead to antibacterial resistance as well as toxicity for plants, animals, or humans. Hence, the objective was to describe the rate of antimicrobial excretion in urine in order to select the most appropriate molecule while reducing harmful effects. Thus, 62 pigs were treated with sulfamethoxypyridazine, oxytetracycline, and enrofloxacin. Urine was collected through the withdrawal period and analysed via LC-MS/MS. Oxytetracycline had the slowest rate of degradation (a half-life time of 4.18 days) and the most extended elimination period in urine (over 2 months), followed by enrofloxacin (a half-life time of 1.48 days, total urine elimination in ca. 3 weeks) and sulfamethoxypyridazine (a half-life time of 0.49 days, total urine elimination in ca. 1 week). Bacterial sensitivity and recommendations for responsible use are limiting when selecting the treatment. Nevertheless, with similar effectiveness, sulfamethoxypyridazine would be the choice, as waste treatment would only need to be implemented for 1 week after treatment. Thus, more in-depth knowledge regarding antibacterial elimination would improve resource management, while protecting animals and consumers’ health.
000106733 536__ $$9info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA-2014-2020
000106733 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000106733 590__ $$a5.222$$b2021
000106733 592__ $$a0.785$$b2021
000106733 594__ $$a3.9$$b2021
000106733 591__ $$aPHARMACOLOGY & PHARMACY$$b68 / 279 = 0.244$$c2021$$dQ1$$eT1
000106733 593__ $$aBiochemistry$$c2021$$dQ1
000106733 591__ $$aINFECTIOUS DISEASES$$b39 / 96 = 0.406$$c2021$$dQ2$$eT2
000106733 593__ $$aMicrobiology$$c2021$$dQ1
000106733 593__ $$aPharmacology, Toxicology and Pharmaceutics (miscellaneous)$$c2021$$dQ1
000106733 593__ $$aPharmacology (medical)$$c2021$$dQ1
000106733 593__ $$aMicrobiology (medical)$$c2021$$dQ1
000106733 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000106733 700__ $$0(orcid)0000-0002-7629-8101$$aGarcía-Gonzalo, Diego$$uUniversidad de Zaragoza
000106733 700__ $$aElorduy Goyeneche, Janire
000106733 700__ $$0(orcid)0000-0001-9907-2941$$aMitjana Nerín, Olga$$uUniversidad de Zaragoza
000106733 700__ $$0(orcid)0000-0001-6964-7011$$aFalceto Recio, Mª Victoria$$uUniversidad de Zaragoza
000106733 700__ $$0(orcid)0000-0003-0296-1617$$aLaborda García, Alicia$$uUniversidad de Zaragoza
000106733 700__ $$0(orcid)0000-0001-6178-9891$$aBonastre Ráfales, Cristina$$uUniversidad de Zaragoza
000106733 700__ $$aMata Vallespín, Luis
000106733 700__ $$0(orcid)0000-0002-1902-0648$$aCondón Usón, Santiago$$uUniversidad de Zaragoza
000106733 700__ $$0(orcid)0000-0002-0238-6328$$aPagán Tomás, Rafael.$$uUniversidad de Zaragoza
000106733 7102_ $$11009$$2617$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Medicina y Cirugía Animal
000106733 7102_ $$12008$$2780$$aUniversidad de Zaragoza$$bDpto. Produc.Animal Cienc.Ali.$$cÁrea Tecnología de Alimentos
000106733 773__ $$g10, 7 (2021), 762 [14 pp.]$$pAntibiotics$$tAntibiotics$$x2079-6382
000106733 8564_ $$s1943997$$uhttps://zaguan.unizar.es/record/106733/files/texto_completo.pdf$$yVersión publicada
000106733 8564_ $$s2880796$$uhttps://zaguan.unizar.es/record/106733/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000106733 909CO $$ooai:zaguan.unizar.es:106733$$particulos$$pdriver
000106733 951__ $$a2023-05-18-13:55:41
000106733 980__ $$aARTICLE