106733 20230519145411.0 doi 10.3390/antibiotics10070762 sideral 124549 ART-2021-124549 eng Serrano Andrés, María Jesús (orcid)0000-0003-3850-9833 Antibacterial residue excretion via urine as an indicator for therapeutical treatment choice and farm waste treatment 2021 Access copy available to the general public Unrestricted Many of the infectious diseases that affect livestock have bacteria as etiological agents. Thus, therapy is based on antimicrobials that leave the animal’s tissues mainly via urine, reaching the environment through slurry and waste water. Once there, antimicrobial residues may lead to antibacterial resistance as well as toxicity for plants, animals, or humans. Hence, the objective was to describe the rate of antimicrobial excretion in urine in order to select the most appropriate molecule while reducing harmful effects. Thus, 62 pigs were treated with sulfamethoxypyridazine, oxytetracycline, and enrofloxacin. Urine was collected through the withdrawal period and analysed via LC-MS/MS. Oxytetracycline had the slowest rate of degradation (a half-life time of 4.18 days) and the most extended elimination period in urine (over 2 months), followed by enrofloxacin (a half-life time of 1.48 days, total urine elimination in ca. 3 weeks) and sulfamethoxypyridazine (a half-life time of 0.49 days, total urine elimination in ca. 1 week). Bacterial sensitivity and recommendations for responsible use are limiting when selecting the treatment. Nevertheless, with similar effectiveness, sulfamethoxypyridazine would be the choice, as waste treatment would only need to be implemented for 1 week after treatment. Thus, more in-depth knowledge regarding antibacterial elimination would improve resource management, while protecting animals and consumers’ health. info:eu-repo/grantAgreement/EUR/INTERREG-V-A-POCTEFA-2014-2020 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.222 2021 PHARMACOLOGY & PHARMACY 68 / 279 = 0.244 2021 Q1 T1 INFECTIOUS DISEASES 39 / 96 = 0.406 2021 Q2 T2 0.785 2021 Biochemistry 2021 Q1 Microbiology 2021 Q1 Pharmacology, Toxicology and Pharmaceutics (miscellaneous) 2021 Q1 Pharmacology (medical) 2021 Q1 Microbiology (medical) 2021 Q1 3.9 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion García-Gonzalo, Diego Universidad de Zaragoza (orcid)0000-0002-7629-8101 Elorduy Goyeneche, Janire Mitjana Nerín, Olga Universidad de Zaragoza (orcid)0000-0001-9907-2941 Falceto Recio, Mª Victoria Universidad de Zaragoza (orcid)0000-0001-6964-7011 Laborda García, Alicia Universidad de Zaragoza (orcid)0000-0003-0296-1617 Bonastre Ráfales, Cristina Universidad de Zaragoza (orcid)0000-0001-6178-9891 Mata Vallespín, Luis Condón Usón, Santiago Universidad de Zaragoza (orcid)0000-0002-1902-0648 Pagán Tomás, Rafael. Universidad de Zaragoza (orcid)0000-0002-0238-6328 1009 617 Universidad de Zaragoza Dpto. Patología Animal Área Medicina y Cirugía Animal 2008 780 Universidad de Zaragoza Dpto. Produc.Animal Cienc.Ali. Área Tecnología de Alimentos 10, 7 (2021), 762 [14 pp.] Antibiotics Antibiotics 2079-6382 1943997 http://zaguan.unizar.es/record/106733/files/texto_completo.pdf Versión publicada 2880796 http://zaguan.unizar.es/record/106733/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:106733 articulos driver 2023-05-18-13:55:41 ARTICLE