000106738 001__ 106738
000106738 005__ 20230519145440.0
000106738 0247_ $$2doi$$a10.1007/s12035-021-02489-5
000106738 0248_ $$2sideral$$a124702
000106738 037__ $$aART-2021-124702
000106738 041__ $$aeng
000106738 100__ $$0(orcid)0000-0002-0388-9429$$aBetancor, M.$$uUniversidad de Zaragoza
000106738 245__ $$aTherapeutic assay with the non-toxic c-terminal fragment of tetanus toxin (TTC) in transgenic murine models of prion disease
000106738 260__ $$c2021
000106738 5060_ $$aAccess copy available to the general public$$fUnrestricted
000106738 5203_ $$aThe non-toxic C-terminal fragment of the tetanus toxin (TTC) has been described as a neuroprotective molecule since it binds to Trk receptors and activates Trk-dependent signaling, activating neuronal survival pathways and inhibiting apoptosis. Previous in vivo studies have demonstrated the ability of this molecule to increase mice survival, inhibit apoptosis and regulate autophagy in murine models of neurodegenerative diseases such as amyotrophic lateral sclerosis and spinal muscular atrophy. Prion diseases are fatal neurodegenerative disorders in which the main pathogenic event is the conversion of the cellular prion protein (PrPC) into an abnormal and misfolded isoform known as PrPSc. These diseases share different pathological features with other neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson’s disease or Alzheimer’s disease. Hitherto, there are no effective therapies to treat prion diseases. Here, we present a pilot study to test the therapeutic potential of TTC to treat prion diseases. C57BL6 wild-type mice and the transgenic mice Tg338, which overexpress PrPC, were intracerebrally inoculated with scrapie prions and then subjected to a treatment consisting of repeated intramuscular injections of TTC. Our results indicate that TTC displays neuroprotective effects in the murine models of prion disease reducing apoptosis, regulating autophagy and therefore increasing neuronal survival, although TTC did not increase survival time in these models.
000106738 536__ $$9info:eu-repo/grantAgreement/ES/DGA/A19-20R$$9info:eu-repo/grantAgreement/EUR/FEDER/INTERREG-V-A-POCTEFA-2014-2020
000106738 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000106738 590__ $$a5.686$$b2021
000106738 592__ $$a1.271$$b2021
000106738 594__ $$a11.0$$b2021
000106738 591__ $$aNEUROSCIENCES$$b69 / 275 = 0.251$$c2021$$dQ2$$eT1
000106738 593__ $$aNeurology$$c2021$$dQ1
000106738 593__ $$aCellular and Molecular Neuroscience$$c2021$$dQ1
000106738 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000106738 700__ $$0(orcid)0000-0002-7277-4318$$aMoreno Martínez, L.$$uUniversidad de Zaragoza
000106738 700__ $$0(orcid)0000-0003-2454-2114$$aLópez-Pérez, Ó.
000106738 700__ $$0(orcid)0000-0001-9075-2764$$aOtero, A.$$uUniversidad de Zaragoza
000106738 700__ $$0(orcid)0000-0002-6806-9990$$aHernaiz, A.$$uUniversidad de Zaragoza
000106738 700__ $$aBarrio, T.
000106738 700__ $$0(orcid)0000-0002-7173-7216$$aBadiola, J.J.$$uUniversidad de Zaragoza
000106738 700__ $$0(orcid)0000-0001-5687-6704$$aOsta, R.$$uUniversidad de Zaragoza
000106738 700__ $$0(orcid)0000-0002-2746-3932$$aBolea, R.$$uUniversidad de Zaragoza
000106738 700__ $$0(orcid)0000-0001-6016-4726$$aMartín Burriel, I.$$uUniversidad de Zaragoza
000106738 7102_ $$11001$$2420$$aUniversidad de Zaragoza$$bDpto. Anatom.,Embri.Genét.Ani.$$cÁrea Genética
000106738 7102_ $$11009$$2773$$aUniversidad de Zaragoza$$bDpto. Patología Animal$$cÁrea Sanidad Animal
000106738 7102_ $$11012$$2315$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Farmacología
000106738 773__ $$g58 (2021), 5312–5326$$pMol. neurobiol.$$tMOLECULAR NEUROBIOLOGY$$x0893-7648
000106738 8564_ $$s21349733$$uhttps://zaguan.unizar.es/record/106738/files/texto_completo.pdf$$yVersión publicada
000106738 8564_ $$s2408577$$uhttps://zaguan.unizar.es/record/106738/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000106738 909CO $$ooai:zaguan.unizar.es:106738$$particulos$$pdriver
000106738 951__ $$a2023-05-18-14:29:56
000106738 980__ $$aARTICLE