000107327 001__ 107327
000107327 005__ 20230519145348.0
000107327 0247_ $$2doi$$a10.1111/bpa.12896
000107327 0248_ $$2sideral$$a120325
000107327 037__ $$aART-2021-120325
000107327 041__ $$aeng
000107327 100__ $$aPascual, M.
000107327 245__ $$aRole of mTOR-regulated autophagy in spine pruning defects and memory impairments induced by binge-like ethanol treatment in adolescent mice
000107327 260__ $$c2021
000107327 5060_ $$aAccess copy available to the general public$$fUnrestricted
000107327 5203_ $$aAdolescence is a brain maturation developmental period during which remodeling and changes in synaptic plasticity and neural connectivity take place in some brain regions. Different mechanism participates in adolescent brain maturation, including autophagy that plays a role in synaptic development and plasticity. Alcohol is a neurotoxic compound and its abuse in adolescence induces neuroinflammation, synaptic and myelin alterations, neural damage and behavioral impairments. Changes in synaptic plasticity and its regulation by mTOR have also been suggested to play a role in the behavioral dysfunction of binge ethanol drinking in adolescence. Therefore, by considering the critical role of mTOR in both autophagy and synaptic plasticity in the developing brain, the present study aims to evaluate whether binge ethanol treatment in adolescence would induce dysfunctions in synaptic plasticity and cognitive functions and if mTOR inhibition with rapamycin is capable of restoring both effects. Using C57BL/6 adolescent female and male mice (PND30) treated with ethanol (3 g/kg) on two consecutive days at 48-hour intervals over 2 weeks, we show that binge ethanol treatment alters the density and morphology of dendritic spines, effects that are associated with learning and memory impairments and changes in the levels of both transcription factor CREB phosphorylation and miRNAs. Rapamycin administration (3 mg/kg) prior to ethanol administration restores ethanol-induced changes in both plasticity and behavior dysfunctions in adolescent mice. These results support the critical role of mTOR/autophagy dysfunctions in the dendritic spines alterations and cognitive alterations induced by binge alcohol in adolescence.
000107327 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0004$$9info:eu-repo/grantAgreement/ES/ISCIII-FEDER/RD16-0017-0007$$9info:eu-repo/grantAgreement/ES/MINECO/PSI2017-83023-R
000107327 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000107327 590__ $$a7.611$$b2021
000107327 591__ $$aCLINICAL NEUROLOGY$$b23 / 212 = 0.108$$c2021$$dQ1$$eT1
000107327 591__ $$aPATHOLOGY$$b8 / 77 = 0.104$$c2021$$dQ1$$eT1
000107327 591__ $$aNEUROSCIENCES$$b36 / 275 = 0.131$$c2021$$dQ1$$eT1
000107327 594__ $$a10.4$$b2021
000107327 592__ $$a1.775$$b2021
000107327 593__ $$aNeuroscience (miscellaneous)$$c2021$$dQ1
000107327 593__ $$aNeurology (clinical)$$c2021$$dQ1
000107327 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/submittedVersion
000107327 700__ $$aLópez-Hidalgo, R.
000107327 700__ $$0(orcid)0000-0002-3380-7252$$aMontagud-Romero, S.$$uUniversidad de Zaragoza
000107327 700__ $$aUreña-Peralta, J.R.
000107327 700__ $$aRodríguez-Arias, M.
000107327 700__ $$aGuerri, C.
000107327 7102_ $$14009$$2735$$aUniversidad de Zaragoza$$bDpto. Psicología y Sociología$$cÁrea Psicolog.Evolut.Educac
000107327 773__ $$g31, 1 (2021), 174-188$$pBrain pathol.$$tBRAIN PATHOLOGY$$x1015-6305
000107327 8564_ $$s1254769$$uhttps://zaguan.unizar.es/record/107327/files/texto_completo.pdf$$yPreprint
000107327 8564_ $$s1094283$$uhttps://zaguan.unizar.es/record/107327/files/texto_completo.jpg?subformat=icon$$xicon$$yPreprint
000107327 909CO $$ooai:zaguan.unizar.es:107327$$particulos$$pdriver
000107327 951__ $$a2023-05-18-13:23:53
000107327 980__ $$aARTICLE