000107335 001__ 107335
000107335 005__ 20210913154736.0
000107335 0247_ $$2doi$$a10.1039/d0bm01013h
000107335 0248_ $$2sideral$$a121249
000107335 037__ $$aART-2020-121249
000107335 041__ $$aeng
000107335 100__ $$aRodrigo, M.J.
000107335 245__ $$aBrimonidine-LAPONITE® intravitreal formulation has an ocular hypotensive and neuroprotective effect throughout 6 months of follow-up in a glaucoma animal model
000107335 260__ $$c2020
000107335 5060_ $$aAccess copy available to the general public$$fUnrestricted
000107335 5203_ $$aIntravitreal administration is widely used in ophthalmological practice to maintain therapeutic drug levels near the neuroretina and because drug delivery systems are necessary to avoid reinjections and sight-threatening side effects. However, currently there is no intravitreal treatment for glaucoma. The brimonidine-LAPONITE® formulation was created with the aim of treating glaucoma for extended periods with a single intravitreal injection. Glaucoma was induced by producing ocular hypertension in two rat cohorts: [BRI-LAP] and [non-bri], with and without treatment, respectively. Eyes treated with brimonidine-LAPONITE® showed lower ocular pressure levels up to week 8 (p < 0.001), functional neuroprotection explored by scotopic and photopic negative response electroretinography (p = 0.042), and structural protection of the retina, retinal nerve fibre layer and ganglion cell layer (p = 0.038), especially on the superior-inferior axis explored by optical coherence tomography, which was corroborated by a higher retinal ganglion cell count (p = 0.040) using immunohistochemistry (Brn3a antibody) up to the end of the study (week 24). Furthermore, delayed neuroprotection was detected in the contralateral eye. Brimonidine was detected in treated rat eyes for up to 6 months. Brimonidine-LAPONITE® seems to be a potential sustained-delivery intravitreal drug for glaucoma treatment.
000107335 536__ $$9info:eu-repo/grantAgreement/ES/ISCIII/M17-00213$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01726$$9info:eu-repo/grantAgreement/ES/ISCIII/PI17-01946$$9info:eu-repo/grantAgreement/ES/MINECO-AEI-FEDER/MAT2017-83858-C2-2
000107335 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000107335 590__ $$a6.843$$b2020
000107335 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b8 / 40 = 0.2$$c2020$$dQ1$$eT1
000107335 592__ $$a1.421$$b2020
000107335 593__ $$aMaterials Science (miscellaneous)$$c2020$$dQ1
000107335 593__ $$aBiomedical Engineering$$c2020$$dQ1
000107335 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000107335 700__ $$0(orcid)0000-0002-7914-4685$$aCardiel, M.J.$$uUniversidad de Zaragoza
000107335 700__ $$0(orcid)0000-0002-0136-5138$$aFraile, J.M.$$uUniversidad de Zaragoza
000107335 700__ $$0(orcid)0000-0001-6072-1545$$aMendez-Martinez, S.$$uUniversidad de Zaragoza
000107335 700__ $$aMartinez-Rincon, T.
000107335 700__ $$aSubias, M.
000107335 700__ $$0(orcid)0000-0002-1402-3129$$aPolo, V.$$uUniversidad de Zaragoza
000107335 700__ $$aRuberte, J.
000107335 700__ $$aRamirez, T.
000107335 700__ $$0(orcid)0000-0002-4921-4734$$aVispe, E.
000107335 700__ $$0(orcid)0000-0003-2158-9777$$aLuna, C.
000107335 700__ $$0(orcid)0000-0003-1570-4257$$aMayoral, J.A.$$uUniversidad de Zaragoza
000107335 700__ $$0(orcid)0000-0001-6258-2489$$aGarcia-Martin, E.$$uUniversidad de Zaragoza
000107335 7102_ $$12013$$2765$$aUniversidad de Zaragoza$$bDpto. Química Orgánica$$cÁrea Química Orgánica
000107335 7102_ $$11013$$2646$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Oftalmología
000107335 7102_ $$11013$$2020$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Anatomía Patológica
000107335 773__ $$g8, 22 (2020), 6246-6260$$pBiomater. sci.$$tBiomaterials science$$x2047-4830
000107335 8564_ $$s441865$$uhttps://zaguan.unizar.es/record/107335/files/texto_completo.pdf$$yPostprint
000107335 8564_ $$s2556331$$uhttps://zaguan.unizar.es/record/107335/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000107335 909CO $$ooai:zaguan.unizar.es:107335$$particulos$$pdriver
000107335 951__ $$a2021-09-13-13:17:33
000107335 980__ $$aARTICLE