000107398 001__ 107398
000107398 005__ 20210930091335.0
000107398 0247_ $$2doi$$a10.1039/d0fo01497d
000107398 0248_ $$2sideral$$a121255
000107398 037__ $$aART-2020-121255
000107398 041__ $$aeng
000107398 100__ $$aLes, F.
000107398 245__ $$aRock tea (Jasonia glutinosa (L.) DC.) polyphenolic extract inhibits triglyceride accumulation in 3T3-L1 adipocyte-like cells and obesity related enzymes in vitro
000107398 260__ $$c2020
000107398 5060_ $$aAccess copy available to the general public$$fUnrestricted
000107398 5203_ $$aJasonia glutinosa (L.) DC., also known in Spain as "té de roca" (rock tea, RT), is an endemic plant species of the Iberian Peninsula and Southern France. Traditionally, it is used in infusions, prepared with the flowering aerial parts, as a digestive and anti-inflammatory herbal tea. Despite the traditional knowledge of this plant as a digestive after meals, there are hardly any scientific studies that support its use. The aim of this study is to assess the effects of RT extract on physiological targets related to metabolic diseases such as obesity. For this purpose, enzyme inhibition bioassays of lipase, a-glucosidase and fatty acid amide hydrolase were carried out in cell-free systems. Similarly, adipocytes derived from 3T3-L1 cells were employed to study the effects of the extract on adipocyte differentiation and triglyceride (TG) accumulation. RT extract was able to inhibit lipase, a-glucosidase and fatty acid amide hydrolase. Furthermore, the extract displayed anti-adipogenic properties in a dose-dependent manner as it significantly reduced TG accumulation during adipocyte differentiation. These results may explain from a molecular perspective the beneficial effects of RT in the prevention of metabolic-associated disorders such as obesity, diabetes and related complications.
000107398 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B44-20D$$9info:eu-repo/grantAgreement/ES/USJ-UZ/JIUZ-2018-BIO-09
000107398 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000107398 590__ $$a5.396$$b2020
000107398 591__ $$aFOOD SCIENCE & TECHNOLOGY$$b22 / 144 = 0.153$$c2020$$dQ1$$eT1
000107398 591__ $$aBIOCHEMISTRY & MOLECULAR BIOLOGY$$b76 / 297 = 0.256$$c2020$$dQ2$$eT1
000107398 592__ $$a1.145$$b2020
000107398 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000107398 593__ $$aFood Science$$c2020$$dQ1
000107398 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000107398 700__ $$aCásedas, G.
000107398 700__ $$0(orcid)0000-0002-2231-7565$$aValero, M.S.$$uUniversidad de Zaragoza
000107398 700__ $$0(orcid)0000-0002-8982-3737$$aArbonés-Mainar, J.M.
000107398 700__ $$0(orcid)0000-0001-6969-1055$$aLópez, V.
000107398 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000107398 773__ $$g11, 10 (2020), 8931-8938$$pFOOD & FUNCTION$$tFood & function$$x2042-6496
000107398 8564_ $$s313352$$uhttps://zaguan.unizar.es/record/107398/files/texto_completo.pdf$$yPostprint
000107398 8564_ $$s2654686$$uhttps://zaguan.unizar.es/record/107398/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000107398 909CO $$ooai:zaguan.unizar.es:107398$$particulos$$pdriver
000107398 951__ $$a2021-09-30-08:23:07
000107398 980__ $$aARTICLE