107403 20250109150035.0 doi 10.1038/s41598-021-95282-2 sideral 124758 ART-2021-124758 eng Armañac-Julian, Pablo Universidad de Zaragoza (orcid)0000-0001-5918-1043 Cardiopulmonary coupling indices to assess weaning readiness from mechanical ventilation 2021 Access copy available to the general public Unrestricted The ideal moment to withdraw respiratory supply of patients under Mechanical Ventilation at Intensive Care Units (ICU), is not easy to be determined for clinicians. Although the Spontaneous Breathing Trial (SBT) provides a measure of the patients’ readiness, there is still around 15–20% of predictive failure rate. This work is a proof of concept focused on adding new value to the prediction of the weaning outcome. Heart Rate Variability (HRV) and Cardiopulmonary Coupling (CPC) methods are evaluated as new complementary estimates to assess weaning readiness. The CPC is related to how the mechanisms regulating respiration and cardiac pumping are working simultaneously, and it is defined from HRV in combination with respiratory information. Three different techniques are used to estimate the CPC, including Time-Frequency Coherence, Dynamic Mutual Information and Orthogonal Subspace Projections. The cohort study includes 22 patients in pressure support ventilation, ready to undergo the SBT, analysed in the 24 h previous to the SBT. Of these, 13 had a successful weaning and 9 failed the SBT or needed reintubation –being both considered as failed weaning. Results illustrate that traditional variables such as heart rate, respiratory frequency, and the parameters derived from HRV do not differ in patients with successful or failed weaning. Results revealed that HRV parameters can vary considerably depending on the time at which they are measured. This fact could be attributed to circadian rhythms, having a strong influence on HRV values. On the contrary, significant statistical differences are found in the proposed CPC parameters when comparing the values of the two groups, and throughout the whole recordings. In addition, differences are greater at night, probably because patients with failed weaning might be experiencing more respiratory episodes, e.g. apneas during the night, which is directly related to a reduced respiratory sinus arrhythmia. Therefore, results suggest that the traditional measures could be used in combination with the proposed CPC biomarkers to improve weaning readiness. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FSE/T39-20R-BSICoS group info:eu-repo/grantAgreement/EC/H2020/745755/EU/Wearable Cardiorespiratory Monitor/WECARMON This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No H2020 745755-WECARMON info:eu-repo/grantAgreement/ES/ISCIII/PI16-01706 info:eu-repo/grantAgreement/ES/ISCIII/PI19-01015 info:eu-repo/grantAgreement/ES/MINECO-FEDER/RTI2018-097723-B-I00 info:eu-repo/grantAgreement/ES/MINECO/RTC-2017-6193-1 info:eu-repo/grantAgreement/ES/UZ-IBERCAJA-CAI/IT9-19 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.997 2021 MULTIDISCIPLINARY SCIENCES 19 / 74 = 0.257 2021 Q2 T1 1.005 2021 Multidisciplinary 2021 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Hernando, David (orcid)0000-0002-1462-4880 Lázaro, Jesús Universidad de Zaragoza (orcid)0000-0001-8742-0072 Haro, Candelaria de Magrans, Rudys Morales, John Moeyersons, Jonathan Sarlabous, Leonardo López-Aguilar, Josefina Subirà, Carles Fernández, Rafael Orini, Michele Laguna, Pablo Universidad de Zaragoza (orcid)0000-0003-3434-9254 Varon, Carolina Gil, Eduardo Universidad de Zaragoza (orcid)0000-0001-7285-0715 Bailón, Raquel Universidad de Zaragoza (orcid)0000-0003-1272-0550 Blanch, Lluís 5007 520 Universidad de Zaragoza Dpto. Informát.Ingenie.Sistms. Área Ingen.Sistemas y Automát. 5008 800 Universidad de Zaragoza Dpto. Ingeniería Electrón.Com. Área Teoría Señal y Comunicac. 11 (2021), [14 pp.] Sci. rep. (Nat. Publ. Group) Scientific reports (Nature Publishing Group) 2045-2322 1591716 http://zaguan.unizar.es/record/107403/files/texto_completo.pdf Versión publicada 2602609 http://zaguan.unizar.es/record/107403/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:107403 articulos driver 2025-01-09-14:59:01 ARTICLE