000107410 001__ 107410 000107410 005__ 20230519145427.0 000107410 0247_ $$2doi$$a10.26355/eurrev_202104_25543 000107410 0248_ $$2sideral$$a124866 000107410 037__ $$aART-2021-124866 000107410 041__ $$aeng 000107410 100__ $$aLedda, C. 000107410 245__ $$aPesticide exposure and gender discrepancy in breast cancer 000107410 260__ $$c2021 000107410 5060_ $$aAccess copy available to the general public$$fUnrestricted 000107410 5203_ $$aOBJECTIVE: It is biologically plausible that occupational and environmental pesticide exposure may contribute to breast cancer risk. Persistent chemical compounds, such as pesticides, tend to be lipophilic and are detected in human breast milk and adipose tissue. Therefore, the present systematic review ims to clarify the gender difference in breast cancer concerning pesticide exposure.MATERIALS AND METHODS: A total of 70 studies satisfied the inclusion criteria and were included in the systematic review. RESULTS: From the studies analyzed, it was observed that exposure to pesticides could be a risk factor for breast cancer in women, in particular in young women and in women who experienced menarche at a young age. In contrast, no association was found for breast cancer in men. Female breast cancer is correlated with estrogen receptor-negative tumor characteristics. Breast cancer in men was no correlated with pesticide exposure. CONCLUSIONS: Breast cancer in women has been linked to estrogen receptor positivity, but this positivity appears to be inversely related to fertility. The estrogen-like effects of organochlorine pesticides could be the cause of the observed gender differences. 000107410 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/ 000107410 590__ $$a3.784$$b2021 000107410 592__ $$a0.658$$b2021 000107410 594__ $$a6.0$$b2021 000107410 591__ $$aPHARMACOLOGY & PHARMACY$$b125 / 279 = 0.448$$c2021$$dQ2$$eT2 000107410 593__ $$aPharmacology (medical)$$c2021$$dQ2 000107410 593__ $$aMedicine (miscellaneous)$$c2021$$dQ2 000107410 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion 000107410 700__ $$aBracci, M. 000107410 700__ $$aLovreglio, P 000107410 700__ $$aSenia, P. 000107410 700__ $$aLarrosa, M. 000107410 700__ $$0(orcid)0000-0001-6469-9189$$aMartínez-Jarreta, María Begoña$$uUniversidad de Zaragoza 000107410 700__ $$aRapisarda, V. 000107410 7102_ $$11012$$2613$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Medicina Legal y Forense 000107410 773__ $$g25, 7 (2021), 2898-2915$$pEuropean Review for Medical and Pharmacological Sciences$$tEuropean Review for Medical and Pharmacological Sciences$$x1128-3602 000107410 8564_ $$s693545$$uhttps://zaguan.unizar.es/record/107410/files/texto_completo.pdf$$yVersión publicada 000107410 8564_ $$s2872420$$uhttps://zaguan.unizar.es/record/107410/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada 000107410 909CO $$ooai:zaguan.unizar.es:107410$$particulos$$pdriver 000107410 951__ $$a2023-05-18-14:13:32 000107410 980__ $$aARTICLE