107410 20230519145427.0 doi 10.26355/eurrev_202104_25543 sideral 124866 ART-2021-124866 eng Ledda, C. Pesticide exposure and gender discrepancy in breast cancer 2021 Access copy available to the general public Unrestricted OBJECTIVE: It is biologically plausible that occupational and environmental pesticide exposure may contribute to breast cancer risk. Persistent chemical compounds, such as pesticides, tend to be lipophilic and are detected in human breast milk and adipose tissue. Therefore, the present systematic review ims to clarify the gender difference in breast cancer concerning pesticide exposure.MATERIALS AND METHODS: A total of 70 studies satisfied the inclusion criteria and were included in the systematic review. RESULTS: From the studies analyzed, it was observed that exposure to pesticides could be a risk factor for breast cancer in women, in particular in young women and in women who experienced menarche at a young age. In contrast, no association was found for breast cancer in men. Female breast cancer is correlated with estrogen receptor-negative tumor characteristics. Breast cancer in men was no correlated with pesticide exposure. CONCLUSIONS: Breast cancer in women has been linked to estrogen receptor positivity, but this positivity appears to be inversely related to fertility. The estrogen-like effects of organochlorine pesticides could be the cause of the observed gender differences. info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 3.784 2021 PHARMACOLOGY & PHARMACY 125 / 279 = 0.448 2021 Q2 T2 0.658 2021 Pharmacology (medical) 2021 Q2 Medicine (miscellaneous) 2021 Q2 6.0 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Bracci, M. Lovreglio, P Senia, P. Larrosa, M. Martínez-Jarreta, María Begoña Universidad de Zaragoza (orcid)0000-0001-6469-9189 Rapisarda, V. 1012 613 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Medicina Legal y Forense 25, 7 (2021), 2898-2915 European Review for Medical and Pharmacological Sciences European Review for Medical and Pharmacological Sciences 1128-3602 693545 http://zaguan.unizar.es/record/107410/files/texto_completo.pdf Versión publicada 2872420 http://zaguan.unizar.es/record/107410/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:107410 articulos driver 2023-05-18-14:13:32 ARTICLE