107457 20230519145410.0 doi 10.3390/ijerph18147238 sideral 124895 ART-2021-124895 eng Perez-Lasierra, Jose Luis Universidad de Zaragoza (orcid)0000-0002-1113-9169 Can Physical Activity Reduce the Risk of Cognitive Decline in Apolipoprotein e4 Carriers? A Systematic Review 2021 Access copy available to the general public Unrestricted Physical activity (PA) reduces the risk of cognitive decline (CD) in the general population. However, little is known about whether the presence of the apolipoprotein E epsilon 4 allele (APOE e4) could modify this beneficial effect. The aim of this systematic review was to analyze and synthetize the scientific evidence related to PA levels and CD risk in cognitively healthy APOE e4 carriers. Four electronic databases were analyzed. Only original articles with longitudinal study design were selected to analyze the relationship between PA and CD in APOE e4 carriers. Five studies were included in the systematic review. All studies except one stated that PA is a protective factor against CD in APOE e4 carriers. Moreover, partial support was found for the hypothesis that a greater amount and intensity of PA are more beneficial in CD prevention. The results support the idea that PA is a protective factor against CD in APOE e4 carriers. Nevertheless, it would be necessary to carry out further studies that would allow these findings to be contrasted. info:eu-repo/grantAgreement/ES/ISCIII/FIS/PI19-00948 info:eu-repo/grantAgreement/ES/MECD/FPU16-02539 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 4.614 2021 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 45 / 183 = 0.246 2021 Q1 T1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH 71 / 210 = 0.338 2021 Q2 T2 ENVIRONMENTAL SCIENCES 100 / 279 = 0.358 2021 Q2 T2 0.814 2021 Pollution 2021 Q1 Health, Toxicology and Mutagenesis 2021 Q1 4.5 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Casajús, Jose Antonio Universidad de Zaragoza (orcid)0000-0002-7215-6931 Casasnovas, José Antonio Universidad de Zaragoza (orcid)0000-0002-9887-2629 Arbones-Mainar, Jose Miguel (orcid)0000-0002-8982-3737 Lobo, Antonio Universidad de Zaragoza (orcid)0000-0002-9098-655X Lobo, Elena Universidad de Zaragoza (orcid)0000-0002-1252-2397 Moreno-Franco, Belén Universidad de Zaragoza (orcid)0000-0003-0604-5042 Gonzalez-Agüero, Alejandro Universidad de Zaragoza (orcid)0000-0002-1132-5906 1006 245 Universidad de Zaragoza Dpto. Fisiatría y Enfermería Área Educación Física y Depor. 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1007 745 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Psiquiatría 1011 615 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Medic.Prevent.Salud Públ. 18, 14 (2021), 7238 [15 p.] Int. j. environ. res. public health International journal of environmental research and public health 1661-7827 597927 http://zaguan.unizar.es/record/107457/files/texto_completo.pdf Versión publicada 2867563 http://zaguan.unizar.es/record/107457/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:107457 articulos driver 2023-05-18-13:54:02 ARTICLE