000108313 001__ 108313
000108313 005__ 20240201145619.0
000108313 0247_ $$2doi$$a10.1016/j.jmbbm.2020.104165
000108313 0248_ $$2sideral$$a121155
000108313 037__ $$aART-2021-121155
000108313 041__ $$aeng
000108313 100__ $$0(orcid)0000-0001-8219-2365$$aCabeza-Gil, I.$$uUniversidad de Zaragoza
000108313 245__ $$aEffect of haptic geometry in C-loop intraocular lenses on optical quality
000108313 260__ $$c2021
000108313 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108313 5203_ $$aThe biomechanical stability of intraocular lenses (IOLs) must achieve high-quality optical performance and clinical outcomes after cataract surgery. For this reason, the quality and performance features of the IOLs should be previously analysed following the Standard ISO 11979-2 and ISO 11979-3. The ISO 11979-3 tries to reproduce the behaviour of the IOL in the capsular bag by compressing the lens between two clamps. With this test, it has been demonstrated that the haptic design is a crucial factor to obtain biomechanical stability. Hence, the main goal of this study was to design an aberration-free aspheric IOL and to study the influence of haptic geometry on the optical quality. For that purpose, 5 hydrophobic IOLs with different haptic design were manufactured and their biomechanical stability was compared experimentally and numerically. The IOLs were classified as stiff and flexible designs depending on their haptic geometry. The biomechanical response was measured by means of the compression force, the axial displacement, the angle of contact or contact area, the decentration, the tilt and the strain energy. The results suggest that in vitro and in silico compression tests present similar responses for the IOLs analysed. Furthermore, the flexible IOL designs presented better biomechanical stability than stiff designs. These results were correlated with the optical performance, where the optical quality decreases with worst biomechanical stability. This numerical methodology provides an indisputable advance regarding IOL designs, leading to reduce costs by exploring a feasible space of solutions during the product design process and prior to manufacturing.
000108313 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R$$9info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R$$9info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021$$9info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN
000108313 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc-nd$$uhttp://creativecommons.org/licenses/by-nc-nd/3.0/es/
000108313 590__ $$a4.042$$b2021
000108313 591__ $$aENGINEERING, BIOMEDICAL$$b48 / 98 = 0.49$$c2021$$dQ2$$eT2
000108313 591__ $$aMATERIALS SCIENCE, BIOMATERIALS$$b27 / 45 = 0.6$$c2021$$dQ3$$eT2
000108313 594__ $$a6.6$$b2021
000108313 592__ $$a0.746$$b2021
000108313 593__ $$aBiomedical Engineering$$c2021$$dQ2
000108313 593__ $$aBiomaterials$$c2021$$dQ2
000108313 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000108313 700__ $$aPérez-Gracia, J.
000108313 700__ $$0(orcid)0000-0002-3979-4528$$aRemón, L.$$uUniversidad de Zaragoza
000108313 700__ $$0(orcid)0000-0001-9713-1813$$aCalvo, B.$$uUniversidad de Zaragoza
000108313 7102_ $$12002$$2647$$aUniversidad de Zaragoza$$bDpto. Física Aplicada$$cÁrea Óptica
000108313 7102_ $$15004$$2605$$aUniversidad de Zaragoza$$bDpto. Ingeniería Mecánica$$cÁrea Mec.Med.Cont. y Teor.Est.
000108313 773__ $$g114 (2021), 104165 [8 pp]$$pJ. mech. behav. boomed. mater.$$tJournal of the Mechanical Behavior of Biomedical Materials$$x1751-6161
000108313 8564_ $$s693471$$uhttps://zaguan.unizar.es/record/108313/files/texto_completo.pdf$$yPostprint
000108313 8564_ $$s2668127$$uhttps://zaguan.unizar.es/record/108313/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000108313 909CO $$ooai:zaguan.unizar.es:108313$$particulos$$pdriver
000108313 951__ $$a2024-02-01-14:52:44
000108313 980__ $$aARTICLE