108313 20240201145619.0 doi 10.1016/j.jmbbm.2020.104165 sideral 121155 ART-2021-121155 eng Cabeza-Gil, I. Universidad de Zaragoza (orcid)0000-0001-8219-2365 Effect of haptic geometry in C-loop intraocular lenses on optical quality 2021 Access copy available to the general public Unrestricted The biomechanical stability of intraocular lenses (IOLs) must achieve high-quality optical performance and clinical outcomes after cataract surgery. For this reason, the quality and performance features of the IOLs should be previously analysed following the Standard ISO 11979-2 and ISO 11979-3. The ISO 11979-3 tries to reproduce the behaviour of the IOL in the capsular bag by compressing the lens between two clamps. With this test, it has been demonstrated that the haptic design is a crucial factor to obtain biomechanical stability. Hence, the main goal of this study was to design an aberration-free aspheric IOL and to study the influence of haptic geometry on the optical quality. For that purpose, 5 hydrophobic IOLs with different haptic design were manufactured and their biomechanical stability was compared experimentally and numerically. The IOLs were classified as stiff and flexible designs depending on their haptic geometry. The biomechanical response was measured by means of the compression force, the axial displacement, the angle of contact or contact area, the decentration, the tilt and the strain energy. The results suggest that in vitro and in silico compression tests present similar responses for the IOLs analysed. Furthermore, the flexible IOL designs presented better biomechanical stability than stiff designs. These results were correlated with the optical performance, where the optical quality decreases with worst biomechanical stability. This numerical methodology provides an indisputable advance regarding IOL designs, leading to reduce costs by exploring a feasible space of solutions during the product design process and prior to manufacturing. info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FSE/T24-20R info:eu-repo/grantAgreement/ES/MCIU/DPI2017-84047-R info:eu-repo/grantAgreement/ES/MINECO/PRE2018-084021 info:eu-repo/grantAgreement/ES/UZ/ICTS NANBIOSIS-SU8 Unit-CIBER-BBN info:eu-repo/semantics/openAccess by-nc-nd http://creativecommons.org/licenses/by-nc-nd/3.0/es/ 4.042 2021 ENGINEERING, BIOMEDICAL 48 / 98 = 0.49 2021 Q2 T2 MATERIALS SCIENCE, BIOMATERIALS 27 / 45 = 0.6 2021 Q3 T2 0.746 2021 Biomedical Engineering 2021 Q2 Biomaterials 2021 Q2 6.6 2021 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Pérez-Gracia, J. Remón, L. Universidad de Zaragoza (orcid)0000-0002-3979-4528 Calvo, B. Universidad de Zaragoza (orcid)0000-0001-9713-1813 2002 647 Universidad de Zaragoza Dpto. Física Aplicada Área Óptica 5004 605 Universidad de Zaragoza Dpto. Ingeniería Mecánica Área Mec.Med.Cont. y Teor.Est. 114 (2021), 104165 [8 pp] J. mech. behav. boomed. mater. Journal of the Mechanical Behavior of Biomedical Materials 1751-6161 693471 http://zaguan.unizar.es/record/108313/files/texto_completo.pdf Postprint 2668127 http://zaguan.unizar.es/record/108313/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:108313 articulos driver 2024-02-01-14:52:44 ARTICLE