000108323 001__ 108323
000108323 005__ 20220503125130.0
000108323 0247_ $$2doi$$a10.2217/epi-2019-0346
000108323 0248_ $$2sideral$$a120919
000108323 037__ $$aART-2020-120919
000108323 041__ $$aeng
000108323 100__ $$aSchoorlemmer, J.
000108323 245__ $$aAltered DNA methylation in human placenta after (suspected) preterm labor
000108323 260__ $$c2020
000108323 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108323 5203_ $$aAim: The aim of this study was to determine if alterations in DNA methylation in the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health.
Methods: We evaluated placental DNA methylation at seven loci differentially methylated in placental pathologies using targeted bisulfite sequencing, in placentas associated with preterm labor (term birth after suspected preterm labor [n = 15] and preterm birth [n = 15]), and controls (n = 15).
Results: DNA methylation levels at the NCAM1 and PLAGL1 loci in placentas associated with preterm labor did differ significantly (p < 0.05) from controls.
Discussion: Specific alterations in methylation patterns indicative of an unfavourable placental environment are associated with preterm labor per se and not restricted to preterm birth.
000108323 536__ $$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B05-17D-2018$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B77$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/B87$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón$$9info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa$$9info:eu-repo/grantAgreement/ES/ISCIII-ERDF/RETICS-RD12-0026$$9info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208$$9info:eu-repo/grantAgreement/ES/ISCIII/PI10-301
000108323 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000108323 590__ $$a4.778$$b2020
000108323 591__ $$aGENETICS & HEREDITY$$b46 / 175 = 0.263$$c2020$$dQ2$$eT1
000108323 592__ $$a1.264$$b2020
000108323 593__ $$aGenetics$$c2020$$dQ2
000108323 593__ $$aCancer Research$$c2020$$dQ2
000108323 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000108323 700__ $$aMacias-Redondo, S.
000108323 700__ $$aStrunk, M.
000108323 700__ $$aRamos-Ruiz, R.
000108323 700__ $$0(orcid)0000-0003-0664-9583$$aCalvo, P.$$uUniversidad de Zaragoza
000108323 700__ $$0(orcid)0000-0001-5134-1006$$aBenito, R.$$uUniversidad de Zaragoza
000108323 700__ $$aPaules, C.
000108323 700__ $$0(orcid)0000-0002-0670-5541$$aOros, D.
000108323 7102_ $$11011$$2630$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Microbiología
000108323 7102_ $$11013$$2645$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Obstetricia y Ginecología
000108323 773__ $$g12, 20 (2020), [14 pp]$$pEPIGENOMICS$$tEPIGENOMICS$$x1750-1911
000108323 8564_ $$s680243$$uhttps://zaguan.unizar.es/record/108323/files/texto_completo.pdf$$yPostprint
000108323 8564_ $$s1692111$$uhttps://zaguan.unizar.es/record/108323/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000108323 909CO $$ooai:zaguan.unizar.es:108323$$particulos$$pdriver
000108323 951__ $$a2022-05-03-12:46:04
000108323 980__ $$aARTICLE