doi:10.2217/epi-2019-0346engSchoorlemmer, J.Macias-Redondo, S.Strunk, M.Ramos-Ruiz, R.Calvo, P.Benito, R.Paules, C.Oros, D.Altered DNA methylation in human placenta after (suspected) preterm laborART-2020-120919Aim: The aim of this study was to determine if alterations in DNA methylation in the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health. Methods: We evaluated placental DNA methylation at seven loci differentially methylated in placental pathologies using targeted bisulfite sequencing, in placentas associated with preterm labor (term birth after suspected preterm labor [n = 15] and preterm birth [n = 15]), and controls (n = 15). Results: DNA methylation levels at the NCAM1 and PLAGL1 loci in placentas associated with preterm labor did differ significantly (p < 0.05) from controls. Discussion: Specific alterations in methylation patterns indicative of an unfavourable placental environment are associated with preterm labor per se and not restricted to preterm birth.2020http://zaguan.unizar.es/record/10832310.2217/epi-2019-0346http://zaguan.unizar.es/record/108323oai:zaguan.unizar.es:108323info:eu-repo/grantAgreement/ES/DGA-FEDER/B05-17D-2018info:eu-repo/grantAgreement/ES/DGA-FEDER/B77info:eu-repo/grantAgreement/ES/DGA-FEDER/B87info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragóninfo:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europainfo:eu-repo/grantAgreement/ES/ISCIII-ERDF/RETICS-RD12-0026info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208info:eu-repo/grantAgreement/ES/ISCIII/PI10-301EPIGENOMICS 12, 20 (2020), [14 pp]All rights reservedhttp://www.europeana.eu/rights/rr-f/info:eu-repo/semantics/openAccess