108323 20220503125130.0 doi 10.2217/epi-2019-0346 sideral 120919 ART-2020-120919 eng Schoorlemmer, J. Altered DNA methylation in human placenta after (suspected) preterm labor 2020 Access copy available to the general public Unrestricted Aim: The aim of this study was to determine if alterations in DNA methylation in the human placenta would support suspected preterm labor as a pathologic insult associated with diminished placental health. Methods: We evaluated placental DNA methylation at seven loci differentially methylated in placental pathologies using targeted bisulfite sequencing, in placentas associated with preterm labor (term birth after suspected preterm labor [n = 15] and preterm birth [n = 15]), and controls (n = 15). Results: DNA methylation levels at the NCAM1 and PLAGL1 loci in placentas associated with preterm labor did differ significantly (p < 0.05) from controls. Discussion: Specific alterations in methylation patterns indicative of an unfavourable placental environment are associated with preterm labor per se and not restricted to preterm birth. info:eu-repo/grantAgreement/ES/DGA-FEDER/B05-17D-2018 info:eu-repo/grantAgreement/ES/DGA-FEDER/B77 info:eu-repo/grantAgreement/ES/DGA-FEDER/B87 info:eu-repo/grantAgreement/ES/DGA-FEDER/Construyendo Europa desde Aragón info:eu-repo/grantAgreement/ES/DGA-FEDER/Una manera de hacer Europa info:eu-repo/grantAgreement/ES/ISCIII-ERDF/RETICS-RD12-0026 info:eu-repo/grantAgreement/ES/ISCIII-FIS/PI17-02208 info:eu-repo/grantAgreement/ES/ISCIII/PI10-301 info:eu-repo/semantics/openAccess All rights reserved http://www.europeana.eu/rights/rr-f/ 4.778 2020 GENETICS & HEREDITY 46 / 175 = 0.263 2020 Q2 T1 1.264 2020 Genetics 2020 Q2 Cancer Research 2020 Q2 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Macias-Redondo, S. Strunk, M. Ramos-Ruiz, R. Calvo, P. Universidad de Zaragoza (orcid)0000-0003-0664-9583 Benito, R. Universidad de Zaragoza (orcid)0000-0001-5134-1006 Paules, C. Oros, D. (orcid)0000-0002-0670-5541 1011 630 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Microbiología 1013 645 Universidad de Zaragoza Dpto. Cirugía Área Obstetricia y Ginecología 12, 20 (2020), [14 pp] EPIGENOMICS EPIGENOMICS 1750-1911 680243 http://zaguan.unizar.es/record/108323/files/texto_completo.pdf Postprint 1692111 http://zaguan.unizar.es/record/108323/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:108323 articulos driver 2022-05-03-12:46:04 ARTICLE