108329 20211115135505.0 doi 10.1039/d0cc06349e sideral 122421 ART-2020-122421 eng Macías-León, J. Universidad de Zaragoza (orcid)0000-0001-6815-6720 Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody 2020 The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody''s contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools. Access copy available to the general public Unrestricted info:eu-repo/grantAgreement/ES/AEI/BFU2016-75633-P info:eu-repo/grantAgreement/ES/AEI/CTQ2013-44367-C2-2-P info:eu-repo/grantAgreement/ES/AEI/PID2019-105451GB-I00 info:eu-repo/grantAgreement/ES/AEI/PID2019-107476GB-I00 info:eu-repo/grantAgreement/ES/AEI/RTI-2018-099592-B-C21 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.222 2020 CHEMISTRY, MULTIDISCIPLINARY 44 / 178 = 0.247 2020 Q1 T1 1.837 2020 Catalysis 2020 Q1 Ceramics and Composites 2020 Q1 Chemistry (miscellaneous) 2020 Q1 Surfaces, Coatings and Films 2020 Q1 Materials Chemistry 2020 Q1 Metals and Alloys 2020 Q1 Electronic, Optical and Magnetic Materials 2020 Q1 info:eu-repo/semantics/article info:eu-repo/semantics/acceptedVersion Bermejo, I.A. Asín, A. García-García, A. Universidad de Zaragoza (orcid)0000-0003-3791-2997 Compañón, I. Jiménez-Moreno, E. Coelho, H. Mangini, V. Albuquerque, I.S. Marcelo, F. Asensio, J.L. Bernardes, G.J.L. Joshi, H.J. Fiammengo, R. Blixt, O. Hurtado-Guerrero, R. Universidad de Zaragoza (orcid)0000-0002-3122-9401 Corzana, F. 1002 060 Universidad de Zaragoza Dpto. Bioq.Biolog.Mol. Celular Área Bioquímica y Biolog.Mole. 56, 96 (2020), 15137-15140 Chem. commun. CHEMICAL COMMUNICATIONS 1359-7345 1442738 http://zaguan.unizar.es/record/108329/files/texto_completo.pdf Postprint 3065220 http://zaguan.unizar.es/record/108329/files/texto_completo.jpg?subformat=icon icon Postprint oai:zaguan.unizar.es:108329 articulos driver 2021-11-15-08:57:01 ARTICLE