000108418 001__ 108418
000108418 005__ 20211115162714.0
000108418 0248_ $$2sideral$$a121557
000108418 037__ $$aART-2020-121557
000108418 041__ $$aeng
000108418 100__ $$aNieto Morcillo, L.
000108418 245__ $$aPredictors Of Positivity Of [F-18]F-Choline PET-CT In Prostate Cancer Recurrence. Preliminary Results
000108418 260__ $$c2020
000108418 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108418 5203_ $$aEP-173
Aim/Introduction: To analyze the validity of [18F]F-Choline PET-CT results in prostate cancer recurrence in our daily practice, based on theoretical cut-off points of prostatespecific antigen (PSA), its kinetic, and PSA doubling time (PSADT), to identify predictors of positivity and modify the indication criteria. Materials and
Methods: Prior to the validity analysis, a descriptive, prospective analysis of consecutive patients with prostate cancer treated with curative intent by radical prostatectomy (RP) or radiotherapy (RT), who underwent PET-CT scan with recurrence criteria: PSA =1 or PSA 0.4-1 with PSADT <6 months after RP; PSA> Nadir + 2 after RT, was performed.
Results: From April to December 2019, 69 patients were included, 40 were treated with RP (58%) and 29 with RT (42%). In 45 patients (65%) PET-CT was able to identify recurrence of the disease (positive PET) and in 24 it was not (negative PET). Of patients treated with RP, 82, 5% (33/40) had PSA>1, and of those, 61% were positive PET. 17, 5% (7/40) had PSA<1 and PSADT< 6 months (28/69), with positive PET in 43% of patients. 76% of patients had a positive PET after RT. Positive PET results were obtained in 57% of patients with PSADT>6months (28/69), in 71% if PSADT<6months (41/69) and in 81% of patients if PSADT<3 months (16/69). After RP and RT, PET was positive in 50% and 62, 5% of patients respectively if PSADT>6 months, in 61% and 92% if PSADT<6 months and in 77% and 100% if PSADT<3 months.
Conclusion: Preliminarily and awaiting validation, it seems that PSA>1 after RP or Nadir +2 after RT is an indicator of PET-CT. There seems to be a tendency that shows that PSA<1 after RP is an indicator of PET-CT if PSADT<3 months. PSADT <3 or <6 months could be the best predictor of positivity of PET-CT with [18F]F-Choline in recurrent prostate cancer.
000108418 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000108418 590__ $$a9.236$$b2020
000108418 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b5 / 134 = 0.037$$c2020$$dQ1$$eT1
000108418 592__ $$a2.313$$b2020
000108418 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2020$$dQ1
000108418 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000108418 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000108418 700__ $$aFalgas Lacueva, M.
000108418 700__ $$0(orcid)0000-0003-0962-7689$$ade la Cueva Barrao, L.$$uUniversidad de Zaragoza
000108418 700__ $$0(orcid)0000-0003-0178-4567$$aBorque Fernando, A.$$uUniversidad de Zaragoza
000108418 700__ $$aMendez Villamon, A.$$uUniversidad de Zaragoza
000108418 700__ $$aGuerrero Fernandez de Alba, I.
000108418 700__ $$aCalderon Calvente, M.
000108418 700__ $$aGuzman Prudencio, G.
000108418 700__ $$aDiez Canseco, L. del Barco
000108418 700__ $$0(orcid)0000-0002-5512-5885$$aAbos Olivares, D.$$uUniversidad de Zaragoza
000108418 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000108418 7102_ $$11013$$2817$$aUniversidad de Zaragoza$$bDpto. Cirugía$$cÁrea Urología
000108418 773__ $$g47, SUPPL 1 (2020), S593$$pEur. J. Nucl. Med. Mol. Imaging$$tEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING$$x1619-7070
000108418 85641 $$uhttps://link.springer.com/content/pdf/10.1007%2Fs00259-020-04988-4.pdf$$zTexto completo de la revista
000108418 8564_ $$s148850$$uhttps://zaguan.unizar.es/record/108418/files/texto_completo.pdf$$yPostprint
000108418 8564_ $$s3092868$$uhttps://zaguan.unizar.es/record/108418/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000108418 909CO $$ooai:zaguan.unizar.es:108418$$particulos$$pdriver
000108418 951__ $$a2021-11-15-12:20:28
000108418 980__ $$aARTICLE