000108419 001__ 108419
000108419 005__ 20211115162714.0
000108419 0248_ $$2sideral$$a121558
000108419 037__ $$aART-2020-121558
000108419 041__ $$aeng
000108419 100__ $$aRoteta, A.
000108419 245__ $$aThe Importance Of Monoclonal Proteins Determination For The Correct Diagnosis Of Transthyretin Cardiac Amyloidosis By [Tc-99m]Tc-diphosphonates
000108419 260__ $$c2020
000108419 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108419 5203_ $$aEPS-066
Aim/Introduction: To analyze the influence of the determination of free monoclonal proteins in blood and urine in the final diagnosis of Transthyretin Cardiac Amyloidosis (TTRA).
Materials and Methods: We have analyzed 200 [99mTc]Tc-diphosphonates scans: 192 performed on 190 patients under suspicion of TTRA and 7 patients with grade II-III radiotracer myocardial deposit as a casual finding (November/2013 - January/2020). Likewise, clinical and laboratory characteristics (heart failure, LVEF, proBNP levels, immunofixation in serum and/or urine for the detection of monoclonal chains and chronic renal failure) have been evaluated. A positive case has been considered for TTRAwt or senile (Score Perugini II-III scan, negative immunofixation in serum and/or urine, negative genetic study), positive case for hereditary TTRA (Score Perugini II-III scan, negative immunofixation and positive genetic study), positive case for secondary amyloidosis (positive immunofixation and presence of hematologic malignancy) and undetermined amyloidosis (immunofixation not performed or positive and absence of haematologic malignancies at follow-up).
Results: 59 positive scans have been detected, 47 men (79’7%) and 12 women (20’3%). The mean age of the group of positives was 82’66 years, while that of the negatives was 72’15. The mean proBNP levels in the positives are 7561, compared to 5869 in the negative group. Immunofixation (serum and/or urine for detection of kappa or lambda monoclonal chains at 30 (50.8%) has been performed on these patients. Finally, 37.2% (22/59) resulted in ATTRwt, 3.4% (2/59) hereditary ATTR (genetic study: variant E54Q and mutation c.424> A (p.Va.122Ile) in exon 4 of TTR) and 1.7% (1/59) secondary amyloidosis. The remaining 34/59 (57.7%) cases were undetermined amyloidosis (6 positive immunofixation and 27 without monoclonal proteins determination).
Conclusion: Determination of monoclonal bands in blood and urine is mandatory to correctly characterize cases of cardiac amyloidosis and, in presence of monoclonal bands, to assess the existence of underlying haematological malignancies.
000108419 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000108419 590__ $$a9.236$$b2020
000108419 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b5 / 134 = 0.037$$c2020$$dQ1$$eT1
000108419 592__ $$a2.313$$b2020
000108419 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2020$$dQ1
000108419 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000108419 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000108419 700__ $$aNogueira Souto, D.
000108419 700__ $$aAndres Gracia, A.
000108419 700__ $$aTardin Cardoso, L.
000108419 700__ $$0(orcid)0000-0002-3914-2511$$aRazola Alba, P.$$uUniversidad de Zaragoza
000108419 700__ $$aDelgado Castro, M.$$uUniversidad de Zaragoza
000108419 700__ $$aEscalera Temprado, T.
000108419 700__ $$0(orcid)0000-0002-7481-1370$$aPrats Rivera, E.$$uUniversidad de Zaragoza
000108419 700__ $$0(orcid)0000-0002-5512-5885$$aAbos Olivares, M.$$uUniversidad de Zaragoza
000108419 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000108419 773__ $$g47, SUPPL 1 (2020), S150-S151$$pEur. J. Nucl. Med. Mol. Imaging$$tEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING$$x1619-7070
000108419 85641 $$uhttps://link.springer.com/content/pdf/10.1007%2Fs00259-020-04988-4.pdf$$zTexto completo de la revista
000108419 8564_ $$s160805$$uhttps://zaguan.unizar.es/record/108419/files/texto_completo.pdf$$yPostprint
000108419 8564_ $$s3155169$$uhttps://zaguan.unizar.es/record/108419/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000108419 909CO $$ooai:zaguan.unizar.es:108419$$particulos$$pdriver
000108419 951__ $$a2021-11-15-12:20:33
000108419 980__ $$aARTICLE