000108420 001__ 108420
000108420 005__ 20211115162714.0
000108420 0248_ $$2sideral$$a121559
000108420 037__ $$aART-2020-121559
000108420 041__ $$aeng
000108420 100__ $$aRoteta, A.
000108420 245__ $$aImpact Of Sentinel Lymph Node Biopsy In Breast Cancer Patients Treated With Neoadjuvant Chemotherapy
000108420 260__ $$c2020
000108420 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108420 5203_ $$aEPS 196
Aim/Introduction: To analyze how many of the patients undergoing neoadjuvant chemotherapy (NCT) may benefit from SLNB, as well as the impact on patient management, especially in those with early axillary involvement.
Materials and Methods: We included patients with breast carcinoma candidates to NCT discussed at the Tumor Committee of our hospital (April/2017-August/2019). All of them were subjected to clinical assessment, ultrasound and, if appropriate, histological analysis, axillary pre and post- NCT. Sentinel lymph node detection was performed after periareolar injection of [99mTc]Tc-nanocoloid (74 MBq) the day before surgery. In some cases, blue dye was injected and/or a pre-NPC metal clip was placed in the affected node.
Results: Sixty-two patients were included. NCT achieved a complete breast response in 12 patients, partial in 46 and non-response in 4. Initially, 31 patients were classified as N0 and 31 as N+ (28 N1 and 3 N2), achieving a complete axillary response in 58% of N+ (18). SLNB was performed in 49 patients (79%; 100% in N0 and 58% in N+ from baseline). The gamma detection rate of the sentinel lymph node was 91.8% (93.5% in N0 and 88.9% in N+). 28 lymphadenectomies were undergone (45.2%; 22.5% in N0 and 67.7% in N+), 11 due to positive SLNB (5 N0 and 6 N1), 13 owing to lack of axillary response and 4 caused by the non-localization of the sentinel lymph node. SLNB was performed in 58% of N+ patients, of which 44.4% were negative, avoiding lymphadenectomy. Metal clip and/or blue dye techniques were used in 31 cases (50%).
Conclusion: SLNB is viable in a high percentage of patients with previous NCT, with a high detection rate, even in patients with early affected axilla, avoiding lymphadenectomy to patients who achieve a complete response of the axillary lymph node.
000108420 540__ $$9info:eu-repo/semantics/openAccess$$aAll rights reserved$$uhttp://www.europeana.eu/rights/rr-f/
000108420 590__ $$a9.236$$b2020
000108420 591__ $$aRADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING$$b5 / 134 = 0.037$$c2020$$dQ1$$eT1
000108420 592__ $$a2.313$$b2020
000108420 593__ $$aRadiology, Nuclear Medicine and Imaging$$c2020$$dQ1
000108420 593__ $$aMedicine (miscellaneous)$$c2020$$dQ1
000108420 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/acceptedVersion
000108420 700__ $$aNogueira Souto, D.
000108420 700__ $$aGalindo Lalana, E.
000108420 700__ $$aTardin Cardoso, L.
000108420 700__ $$aAndres Gracia, A.
000108420 700__ $$0(orcid)0000-0002-3914-2511$$aRazola Alba, P.$$uUniversidad de Zaragoza
000108420 700__ $$aDelgado Castro, M.$$uUniversidad de Zaragoza
000108420 700__ $$aEscalera Temprado, T.
000108420 700__ $$0(orcid)0000-0002-7481-1370$$aPrats Rivera, E.$$uUniversidad de Zaragoza
000108420 700__ $$0(orcid)0000-0002-5512-5885$$aAbos Olivares, M.$$uUniversidad de Zaragoza
000108420 7102_ $$11011$$2770$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Radiol. y Medicina Física
000108420 773__ $$g47, SUPPL 1 (2020), S506-S507$$pEur. J. Nucl. Med. Mol. Imaging$$tEUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING$$x1619-7070
000108420 85641 $$uhttps://link.springer.com/content/pdf/10.1007%2Fs00259-020-04988-4.pdf$$zTexto completo de la revista
000108420 8564_ $$s169720$$uhttps://zaguan.unizar.es/record/108420/files/texto_completo.pdf$$yPostprint
000108420 8564_ $$s3138145$$uhttps://zaguan.unizar.es/record/108420/files/texto_completo.jpg?subformat=icon$$xicon$$yPostprint
000108420 909CO $$ooai:zaguan.unizar.es:108420$$particulos$$pdriver
000108420 951__ $$a2021-11-15-12:20:38
000108420 980__ $$aARTICLE