108511 20260113221443.0 doi 10.3390/jcm10163534 sideral 124811 ART-2021-124811 eng Sánchez-Marteles, Marta Universidad de Zaragoza (orcid)0000-0002-2338-7637 Early Measurement of Blood sST2 Is a Good Predictor of Death and Poor Outcomes in Patients Admitted for COVID-19 Infection 2021 Access copy available to the general public Unrestricted Although several biomarkers have shown correlation to prognosis in COVID-19 patients, their clinical value is limited because of lack of specificity, suboptimal sensibility or poor dynamic behavior. We hypothesized that circulating soluble ST2 (sST2) could be associated to a worse outcome in COVID-19. In total, 152 patients admitted for confirmed COVID-19 were included in a prospective non-interventional, observational study. Blood samples were drawn at admission, 48-72 h later and at discharge. sST2 concentrations and routine blood laboratory were analyzed. Primary endpoints were admission at intensive care unit (ICU) and mortality. Median age was 57.5 years [Standard Deviation (SD: 12.8)], 60.4% males. 10% of patients (n = 15) were derived to ICU and/or died during admission. Median (IQR) sST2 serum concentration (ng/mL) rose to 53.1 (30.9) at admission, peaked at 48-72 h (79.5(64)) and returned to admission levels at discharge (44.9[36.7]). A concentration of sST2 above 58.9 ng/mL was identified patients progressing to ICU admission or death. Results remained significant after multivariable analysis. The area under the receiver operating characteristics curve (AUC) of sST2 for endpoints was 0.776 (p = 0.001). In patients admitted for COVID-19 infection, early measurement of sST2 was able to identify patients at risk of severe complications or death. info:eu-repo/semantics/openAccess by https://creativecommons.org/licenses/by/4.0/deed.es 4.964 2021 MEDICINE, GENERAL & INTERNAL 55 / 172 = 0.32 2021 Q2 T1 1.04 2021 Medicine (miscellaneous) 2021 Q1 4.4 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Rubio-Gracia, Jorge Universidad de Zaragoza (orcid)0000-0002-4769-7154 Peña-Fresneda, Natacha Garcés-Horna, Vanessa Universidad de Zaragoza Gracia-Tello, Borja (orcid)0000-0003-3248-2908 Martínez-Lostao, Luis Universidad de Zaragoza (orcid)0000-0003-3043-147X Crespo-Aznárez, Silvia Pérez-Calvo, Juan Ignacio Universidad de Zaragoza (orcid)0000-0003-2361-9941 Giménez-López, Ignacio Universidad de Zaragoza (orcid)0000-0002-6043-4869 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 1007 610 Universidad de Zaragoza Dpto. Medicina, Psiqu. y Derm. Area Medicina 1011 566 Universidad de Zaragoza Dpto. Microb.Ped.Radio.Sal.Pú. Área Inmunología 10, 16 (2021), 3534 [14 pp.] J. clin.med. Journal of Clinical Medicine 2077-0383 1018858 http://zaguan.unizar.es/record/108511/files/texto_completo.pdf Versión publicada 2743989 http://zaguan.unizar.es/record/108511/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:108511 articulos driver 2026-01-13-22:10:34 ARTICLE