000108598 001__ 108598
000108598 005__ 20211201131443.0
000108598 0247_ $$2doi$$a10.1183/13993003.04283-2020
000108598 0248_ $$2sideral$$a124810
000108598 037__ $$aART-2021-124810
000108598 041__ $$aeng
000108598 100__ $$0(orcid)0000-0002-4769-7154$$aRubio-Gracia, Jorge$$uUniversidad de Zaragoza
000108598 245__ $$aPoint-of-care lung ultrasound assessment for risk stratification and therapy guiding in COVID-19 patients. A prospective non-interventional study.
000108598 260__ $$c2021
000108598 5060_ $$aAccess copy available to the general public$$fUnrestricted
000108598 5203_ $$aBackground Lung ultrasound is feasible for assessing lung injury caused by coronavirus disease 2019 (COVID-19). However, the prognostic meaning and time-line changes of lung injury assessed by lung ultrasound in COVID-19 hospitalised patients are unknown.

Methods Prospective cohort study designed to analyse prognostic value of lung ultrasound in COVID-19 patients by using a quantitative scale (lung ultrasound Zaragoza (LUZ)-score) during the first 72 h after admission. The primary end-point was in-hospital death and/or admission to the intensive care unit. Total length of hospital stay, increase of oxygen flow and escalation of medical treatment during the first 72 h were secondary end-points.

Results 130 patients were included in the final analysis; mean±sd age was 56.7±13.5 years. Median (interquartile range) time from the beginning of symptoms to admission was 6 (4–9) days. Lung injury assessed by LUZ-score did not differ during the first 72 h (21 (16–26) points at admission versus 20 (16–27) points at 72 h; p=0.183). In univariable logistic regression analysis, estimated arterial oxygen tension/inspiratory oxygen fraction ratio (PAFI) (hazard ratio 0.99, 95% CI 0.98–0.99; p=0.027) and LUZ-score >22 points (5.45, 1.42–20.90; p=0.013) were predictors for the primary end-point.

Conclusions LUZ-score is an easy, simple and fast point-of-care ultrasound tool to identify patients with severe lung injury due to COVID-19, upon admission. Baseline score is predictive of severity along the whole period of hospitalisation. The score facilitates early implementation or intensification of treatment for COVID-19 infection. LUZ-score may be combined with clinical variables (as estimated by PAFI) to further refine risk stratification.
000108598 540__ $$9info:eu-repo/semantics/openAccess$$aby-nc$$uhttp://creativecommons.org/licenses/by-nc/3.0/es/
000108598 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000108598 700__ $$0(orcid)0000-0002-6043-4869$$aGiménez-López, Ignacio$$uUniversidad de Zaragoza
000108598 700__ $$aGarcés-Horna, Vanessa$$uUniversidad de Zaragoza
000108598 700__ $$aLópez-Delgado, Daniel
000108598 700__ $$0(orcid)0000-0002-8796-2717$$aSierra-Monzón, José Luis
000108598 700__ $$0(orcid)0000-0003-3043-147X$$aMartínez-Lostao, Luis$$uUniversidad de Zaragoza
000108598 700__ $$0(orcid)0000-0002-8328-9836$$aJosa-Laorden, Claudia$$uUniversidad de Zaragoza
000108598 700__ $$0(orcid)0000-0002-5172-0388$$aRuiz-Laiglesia, Fernando$$uUniversidad de Zaragoza
000108598 700__ $$0(orcid)0000-0003-2361-9941$$aPérez-Calvo, Juan Ignacio$$uUniversidad de Zaragoza
000108598 700__ $$aCrespo-Aznarez, Silvia
000108598 700__ $$aGarcía-Lafuente, J.
000108598 700__ $$aPeña Fresneda, Natacha
000108598 700__ $$0(orcid)0000-0001-6613-0359$$aAmores Arriaga, Beatriz$$uUniversidad de Zaragoza
000108598 700__ $$aGracia-Tello, Borja
000108598 700__ $$0(orcid)0000-0002-2338-7637$$aSánchez-Marteles, Marta$$uUniversidad de Zaragoza
000108598 7102_ $$11005$$2410$$aUniversidad de Zaragoza$$bDpto. Farmacología y Fisiolog.$$cÁrea Fisiología
000108598 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000108598 7102_ $$11011$$2566$$aUniversidad de Zaragoza$$bDpto. Microb.Ped.Radio.Sal.Pú.$$cÁrea Inmunología
000108598 773__ $$g58, 3 (2021), 2004283 [9 pp.]$$pEur. respir. j.$$tEUROPEAN RESPIRATORY JOURNAL$$x0903-1936
000108598 8564_ $$s439815$$uhttps://zaguan.unizar.es/record/108598/files/texto_completo.pdf$$yVersión publicada
000108598 8564_ $$s2859170$$uhttps://zaguan.unizar.es/record/108598/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000108598 909CO $$ooai:zaguan.unizar.es:108598$$particulos$$pdriver
000108598 951__ $$a2021-12-01-12:16:21
000108598 980__ $$aARTICLE