000109038 001__ 109038
000109038 005__ 20240705134134.0
000109038 0247_ $$2doi$$a10.1038/s41598-021-98308-x
000109038 0248_ $$2sideral$$a125215
000109038 037__ $$aART-2021-125215
000109038 041__ $$aeng
000109038 100__ $$0(orcid)0000-0003-1415-146X$$aAznar-Gimeno, Rocío
000109038 245__ $$aChanges in severity, mortality, and virus genome among a Spanish cohort of patients hospitalized with SARS-CoV-2
000109038 260__ $$c2021
000109038 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109038 5203_ $$aComparing pandemic waves could aid in understanding the evolution of COVID-19. The objective of the present study was to compare the characteristics and outcomes of patients hospitalized for COVID-19 in different pandemic waves in terms of severity and mortality. We performed an observational retrospective cohort study of 5,220 patients hospitalized with SARS-CoV-2 infection from February to September 2020 in Aragon, Spain. We compared ICU admissions and 30-day mortality, clinical characteristics, and risk factors of the first and second waves of COVID-19. The SARS-CoV-2 genome was also analyzed in 236 samples. Patients in the first wave (n¿=¿2,547) were older (median age 74 years [IQR 60–86] vs. 70 years [53–85]; p¿<¿0.001) and had worse clinical and analytical parameters related to severe COVID-19 than patients in the second wave (n¿=¿2,673). The probability of ICU admission at 30 days was 16% and 10% (p¿<¿0.001) and the cumulative 30-day mortality rates 38% and 32% in the first and second wave, respectively (p¿=¿0.007). Survival differences were observed among patients aged 60 to 80 years. We also found some variability among death risk factors and the viral genome between waves. Therefore, the two analyzed COVID-19 pandemic waves were different in terms of disease severity and mortality.
000109038 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109038 590__ $$a4.997$$b2021
000109038 592__ $$a1.005$$b2021
000109038 591__ $$aMULTIDISCIPLINARY SCIENCES$$b19 / 74 = 0.257$$c2021$$dQ2$$eT1
000109038 593__ $$aMultidisciplinary$$c2021$$dQ1
000109038 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109038 700__ $$0(orcid)0000-0002-9600-8116$$aPaño-Pardo, J. Ramón$$uUniversidad de Zaragoza
000109038 700__ $$0(orcid)0000-0002-3007-302X$$aEsteban, Luis M.
000109038 700__ $$aLabata-Lezaun, Gorka
000109038 700__ $$aEsquillor-Rodrigo, M. José
000109038 700__ $$0(orcid)0000-0001-5932-2889$$aLanas, Angel$$uUniversidad de Zaragoza
000109038 700__ $$0(orcid)0000-0001-7296-7307$$aAbadía-Gallego, David$$uUniversidad de Zaragoza
000109038 700__ $$aDiez-Fuertes, Francisco
000109038 700__ $$0(orcid)0000-0002-6394-3212$$aTellería-Orriols, Carlos$$uUniversidad de Zaragoza
000109038 700__ $$aHoyo-Alonso, Rafael del
000109038 700__ $$0(orcid)0000-0002-7119-2244$$aSerrano, M. Trinidad$$uUniversidad de Zaragoza
000109038 7102_ $$15007$$2520$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Ingen.Sistemas y Automát.
000109038 7102_ $$11007$$2610$$aUniversidad de Zaragoza$$bDpto. Medicina, Psiqu. y Derm.$$cArea Medicina
000109038 7102_ $$15007$$2570$$aUniversidad de Zaragoza$$bDpto. Informát.Ingenie.Sistms.$$cÁrea Lenguajes y Sistemas Inf.
000109038 773__ $$g11 (2021), 18844 [15 pp.]$$pSci. rep. (Nat. Publ. Group)$$tScientific reports (Nature Publishing Group)$$x2045-2322
000109038 8564_ $$s3681304$$uhttps://zaguan.unizar.es/record/109038/files/texto_completo.pdf$$yVersión publicada
000109038 8564_ $$s2438419$$uhttps://zaguan.unizar.es/record/109038/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109038 909CO $$ooai:zaguan.unizar.es:109038$$particulos$$pdriver
000109038 951__ $$a2024-07-05-12:44:55
000109038 980__ $$aARTICLE