000109048 001__ 109048
000109048 005__ 20230519145421.0
000109048 0247_ $$2doi$$a10.3390/biology10050443
000109048 0248_ $$2sideral$$a125256
000109048 037__ $$aART-2021-125256
000109048 041__ $$aeng
000109048 100__ $$aLes, Francisco
000109048 245__ $$aJasonia glutinosa (L.) DC., a traditional herbal tea, exerts antioxidant and neuroprotective properties in different in vitro and in vivo systems
000109048 260__ $$c2021
000109048 5060_ $$aAccess copy available to the general public$$fUnrestricted
000109048 5203_ $$aIn traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in Caenorhabditis elegans (C. elegans) as an in vivo model, and through in vitro assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of C. elegans CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase in vitro. Together these results demonstrate that Jasonia glutinosa is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests.
000109048 536__ $$9info:eu-repo/grantAgreement/ES/DGA/B44-20D$$9info:eu-repo/grantAgreement/ES/USJ-UZ/JIUZ-2018-BIO-09
000109048 540__ $$9info:eu-repo/semantics/openAccess$$aby$$uhttp://creativecommons.org/licenses/by/3.0/es/
000109048 590__ $$a5.168$$b2021
000109048 592__ $$a0.903$$b2021
000109048 594__ $$a2.8$$b2021
000109048 591__ $$aBIOLOGY$$b21 / 94 = 0.223$$c2021$$dQ1$$eT1
000109048 593__ $$aBiochemistry, Genetics and Molecular Biology (miscellaneous)$$c2021$$dQ1
000109048 593__ $$aAgricultural and Biological Sciences (miscellaneous)$$c2021$$dQ1
000109048 655_4 $$ainfo:eu-repo/semantics/article$$vinfo:eu-repo/semantics/publishedVersion
000109048 700__ $$0(orcid)0000-0002-2231-7565$$aValero, Marta Sofía$$uUniversidad de Zaragoza
000109048 700__ $$aMoliner, Cristina
000109048 700__ $$aWeinkove, David
000109048 700__ $$0(orcid)0000-0001-6969-1055$$aLópez, Víctor
000109048 700__ $$aGómez-Rincón, Carlota
000109048 7102_ $$11012$$2410$$aUniversidad de Zaragoza$$bDpto. Farmac.Fisiol.y Med.L.F.$$cÁrea Fisiología
000109048 773__ $$g10, 5 (2021), 443 [13 pp.]$$tBiology$$x2079-7737
000109048 8564_ $$s1693371$$uhttps://zaguan.unizar.es/record/109048/files/texto_completo.pdf$$yVersión publicada
000109048 8564_ $$s2655119$$uhttps://zaguan.unizar.es/record/109048/files/texto_completo.jpg?subformat=icon$$xicon$$yVersión publicada
000109048 909CO $$ooai:zaguan.unizar.es:109048$$particulos$$pdriver
000109048 951__ $$a2023-05-18-14:06:50
000109048 980__ $$aARTICLE