109048 20230519145421.0 doi 10.3390/biology10050443 sideral 125256 ART-2021-125256 eng Les, Francisco Jasonia glutinosa (L.) DC., a traditional herbal tea, exerts antioxidant and neuroprotective properties in different in vitro and in vivo systems 2021 Access copy available to the general public Unrestricted In traditional medicine, Jasonia glutinosa (L.) DC or rock tea (RT) has been mainly used to treat digestive and respiratory pathologies but also as an antimicrobial or an antidepressant herbal remedy. An ethanolic extract of RT has been demonstrated to have antioxidant and anti-inflammatory effects, which may be explained by its phytochemical profile, rich in polyphenols and pigments. The aim of this study is to investigate the neuroprotective potential of RT. For this purpose, the ethanolic extract of RT is assayed in Caenorhabditis elegans (C. elegans) as an in vivo model, and through in vitro assays using monoamine oxidase A, tyrosinase and acetylcholinesterase as enzymes. The RT extract reduces juglone-induced oxidative stress in worms and increases the lifespan and prevents paralysis of C. elegans CL4176, a model of Alzheimer’s disease; the extract is also able to inhibit enzymes such as acetylcholinesterase, monoamine oxidase A and tyrosinase in vitro. Together these results demonstrate that Jasonia glutinosa is a good candidate with antioxidant and neuroprotective potential for the development of new products with pharmaceutical interests. info:eu-repo/grantAgreement/ES/DGA/B44-20D info:eu-repo/grantAgreement/ES/USJ-UZ/JIUZ-2018-BIO-09 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 5.168 2021 BIOLOGY 21 / 94 = 0.223 2021 Q1 T1 0.903 2021 Biochemistry, Genetics and Molecular Biology (miscellaneous) 2021 Q1 Agricultural and Biological Sciences (miscellaneous) 2021 Q1 2.8 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Valero, Marta Sofía Universidad de Zaragoza (orcid)0000-0002-2231-7565 Moliner, Cristina Weinkove, David López, Víctor (orcid)0000-0001-6969-1055 Gómez-Rincón, Carlota 1012 410 Universidad de Zaragoza Dpto. Farmac.Fisiol.y Med.L.F. Área Fisiología 10, 5 (2021), 443 [13 pp.] Biology 2079-7737 1693371 http://zaguan.unizar.es/record/109048/files/texto_completo.pdf Versión publicada 2655119 http://zaguan.unizar.es/record/109048/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109048 articulos driver 2023-05-18-14:06:50 ARTICLE