109050 20250619084223.0 doi 10.1038/s42005-021-00679-0 sideral 125228 ART-2021-125228 eng Hazarie, Surendra Interplay between population density and mobility in determining the spread of epidemics in cities 2021 Access copy available to the general public Unrestricted The increasing agglomeration of people in dense urban areas coupled with the existence of efficient modes of transportation connecting such centers, make cities particularly vulnerable to the spread of epidemics. Here we develop a data-driven approach combines with a meta-population modeling to capture the interplay between population density, mobility and epidemic spreading. We study 163 cities, chosen from four different continents, and report a global trend where the epidemic risk induced by human mobility increases consistently in those cities where mobility flows are predominantly between high population density centers. We apply our framework to the spread of SARS-CoV-2 in the United States, providing a plausible explanation for the observed heterogeneity in the spreading process across cities. Based on this insight, we propose realistic mitigation strategies (less severe than lockdowns), based on modifying the mobility in cities. Our results suggest that an optimal control strategy involves an asymmetric policy that restricts flows entering the most vulnerable areas but allowing residents to continue their usual mobility patterns. info:eu-repo/grantAgreement/ES/DGA/E19 info:eu-repo/grantAgreement/ES/MINECO/FIS2017-87519-P info:eu-repo/grantAgreement/ES/MINECO/PGC2018-094754-B-C21 info:eu-repo/grantAgreement/ES/MINECO/PID2020-113582GB-I00 info:eu-repo/grantAgreement/ES/UZ-IBERCAJA/224220 info:eu-repo/semantics/openAccess by http://creativecommons.org/licenses/by/3.0/es/ 6.497 2021 PHYSICS, MULTIDISCIPLINARY 16 / 86 = 0.186 2021 Q1 T1 2.13 2021 Physics and Astronomy (miscellaneous) 2021 Q1 8.2 2021 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Soriano-Paños, David Universidad de Zaragoza (orcid)0000-0002-6388-4056 Arenas, Alex Gómez-Gardeñes, Jesús Universidad de Zaragoza (orcid)0000-0001-5204-1937 Ghoshal, Gourab 2003 395 Universidad de Zaragoza Dpto. Física Materia Condensa. Área Física Materia Condensada 4 (2021), 191 [10 pp.] Communications Physics 2399-3650 1291140 http://zaguan.unizar.es/record/109050/files/texto_completo.pdf Versión publicada 1389550 http://zaguan.unizar.es/record/109050/files/texto_completo.jpg?subformat=icon icon Versión publicada oai:zaguan.unizar.es:109050 articulos driver 2025-06-19-08:41:26 ARTICLE